Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

Looking for fragments: A fragment‐based screen using NMR spectroscopy was applied to discover ligands that bind to the GTPase K‐Ras and modulate the activity of the nucleotide exchange factor Sos. Structural data on how these fragment‐derived hits bind to the guanosine diphosphate–K‐Ras complex (see...

Ausführliche Beschreibung