Dibenzophenanthridines as inhibitors of glutaminase C and cancer cell proliferation

One hallmark of cancer cells is their adaptation to rely upon an altered metabolic scheme that includes changes in the glycolytic pathway, known as the Warburg effect, and elevated glutamine metabolism. Glutaminase, a mitochondrial enzyme, plays a key role in the metabolism of glutamine in cancer ce...

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Veröffentlicht in:	Molecular cancer therapeutics 2012-06, Vol.11 (6), p.1269-1278
Hauptverfasser:	Katt, William P, Ramachandran, Sekar, Erickson, Jon W, Cerione, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Benzophenanthridines - chemistry Benzophenanthridines - pharmacology Binding Sites Cell Line, Tumor Cell Proliferation - drug effects Drug Screening Assays, Antitumor Glutaminase - antagonists & inhibitors Glutaminase - metabolism Humans Mice Models, Molecular Phenanthridines - chemistry Phenanthridines - pharmacology Structure-Activity Relationship
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