Microfluidic processor allows rapid HER2 immunohistochemistry of breast carcinomas and significantly reduces ambiguous (2+) read-outs

Biomarker analysis is playing an essential role in cancer diagnosis, prognosis, and prediction. Quantitative assessment of immunohistochemical biomarker expression on tumor tissues is of clinical relevance when deciding targeted treatments for cancer patients. Here, we report a microfluidic tissue p...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-04, Vol.110 (14), p.5363-5368
Hauptverfasser:	Ciftlik, Ata Tuna, Lehr, Hans-Anton, Gijs, Martin A. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Biological markers Biological Sciences Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - pathology Cancer Female Fluorescence Fluorescence in situ hybridization Gene expression Humans Image Processing, Computer-Assisted Immunohistochemistry Immunohistochemistry - methods Kinases Medical diagnosis Medical treatment Microfluidic Analytical Techniques - methods Microscope slides Oncology Pathology Physical Sciences Reagents Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Signal amplification Tissues Tumors
Online-Zugang:	Volltext
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