Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes

Diabetes impinges upon mechanisms of cardiovascular repair. However, the biochemical adaptation of cardiac stem cells to sustained hyperglycaemia remains largely unknown. Here, we investigate the molecular targets of high glucose-induced damage in cardiac progenitor cells (CPCs) from murine and huma...

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Veröffentlicht in:	Cardiovascular research 2013-01, Vol.97 (1), p.55-65
Hauptverfasser:	Katare, Rajesh, Oikawa, Atsuhiko, Cesselli, Daniela, Beltrami, Antonio P, Avolio, Elisa, Muthukrishnan, Deepti, Munasinghe, Pujika Emani, Angelini, Gianni, Emanueli, Costanza, Madeddu, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - metabolism Antigens, Ly - metabolism Apoptosis - drug effects Biomarkers - metabolism Blood Glucose - metabolism Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Type 1 - chemically induced Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - pathology Endoglin Flow Cytometry Glucosephosphate Dehydrogenase - genetics Glucosephosphate Dehydrogenase - metabolism Glycation End Products, Advanced - metabolism Humans Immunohistochemistry Ki-67 Antigen - metabolism Male Membrane Proteins - metabolism Mice Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Oxidative Stress - drug effects Pentose Phosphate Pathway - drug effects Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Proto-Oncogene Proteins c-pim-1 - metabolism Receptors, Cell Surface - metabolism RNA Interference Signal Transduction - drug effects Stem Cells - drug effects Stem Cells - metabolism Stem Cells - pathology Superoxides - metabolism Thiamine - analogs & derivatives Thiamine - pharmacology Transfection Transketolase - metabolism
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