Overexpression of YWHAZ relates to tumor cell proliferation and malignant outcome of gastric carcinoma

Background: Several studies have demonstrated that YWHAZ (14-3-3 ζ ), included in the 14-3-3 family of proteins, has been implicated in the initiation and progression of cancers. We tested whether YWHAZ acted as a cancer-promoting gene through its activation/overexpression in gastric cancer (GC). Me...

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Veröffentlicht in:	British journal of cancer 2013-04, Vol.108 (6), p.1324-1331
Hauptverfasser:	Nishimura, Y, Komatsu, S, Ichikawa, D, Nagata, H, Hirajima, S, Takeshita, H, Kawaguchi, T, Arita, T, Konishi, H, Kashimoto, K, Shiozaki, A, Fujiwara, H, Okamoto, K, Tsuda, H, Otsuji, E
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - antagonists & inhibitors 14-3-3 Proteins - genetics 14-3-3 Proteins - metabolism 692/420/755 692/53/2422 692/699/67/1504 Adult Aged Aged, 80 and over Apoptosis Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Blotting, Western Cancer Research Cancer therapies Cell Adhesion Cell growth Cell Movement Cell Proliferation Drug Resistance Epidemiology Female Follow-Up Studies Gastric cancer Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Profiling Genes Humans Immunoenzyme Techniques Lymphatic Metastasis Male Medical prognosis Medical sciences MicroRNAs - genetics Middle Aged Molecular Diagnostics Molecular Medicine Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Neoplasm Staging Oligonucleotide Array Sequence Analysis Oncology Polyclonal antibodies Prognosis Proteins Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Small Interfering - genetics Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgery Survival Rate Tumor Cells, Cultured Tumors
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