Phantom and mouse experiments of time-domain fluorescence tomography using total light approach
Phantom and mouse experiments of time-domain fluorescence tomography were conducted to demonstrate the total light approach which was previously proposed by authors. The total light approach reduces the computation time to solve the forward model for light propagation. Time-resolved temporal profile...
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| Veröffentlicht in: | Biomedical optics express 2013-04, Vol.4 (4), p.635-651 |
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| creator | Okawa, Shinpei Yano, Akira Uchida, Kazuki Mitsui, Yohei Yoshida, Masaki Takekoshi, Masashi Marjono, Andhi Gao, Feng Hoshi, Yoko Kida, Ikuhiro Masamoto, Kazuto Yamada, Yukio |
| description | Phantom and mouse experiments of time-domain fluorescence tomography were conducted to demonstrate the total light approach which was previously proposed by authors. The total light approach reduces the computation time to solve the forward model for light propagation. Time-resolved temporal profiles were acquired for cylindrical phantoms having single or double targets containing indocyanine green (ICG) solutions. The reconstructed images of ICG concentration reflected the true distributions of ICG concentration with a spatial resolution of about 10 mm. In vivo experiments were conducted using a mouse in which an ICG capsule was embedded beneath the skin in the abdomen. The reconstructed image of the ICG concentration again reflected the true distribution of ICG although artifacts due to autofluorescence appeared in the vicinity of the skin. The effectiveness of the total light approach was demonstrated by the phantom and mouse experiments. |
| doi_str_mv | 10.1364/boe.4.000635 |
| format | Article |
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| ispartof | Biomedical optics express, 2013-04, Vol.4 (4), p.635-651 |
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| language | eng |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Diffuse Optical Imaging |
| title | Phantom and mouse experiments of time-domain fluorescence tomography using total light approach |
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