Inhibition of gastric tumor growth by a novel Hsp90 inhibitor

Heat shock protein 90 (Hsp90) is a molecular chaperone engaging in multiple cellular signaling by stabilizing oncoproteins (e.g. Akt and c-Raf) in tumor cells. Whereas Hsp90 inhibitors such as 17-AAG exert promising antitumor effects in clinical trials, current efforts focus on developing agents tar...

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Veröffentlicht in:	Biochemical pharmacology 2013-05, Vol.85 (9), p.1246-1256
Hauptverfasser:	Lu, Chunwan, Liu, Di, Jin, Jing, Deokar, Hemantkumar, Zhang, Yi, Buolamwini, John K., Yu, Xiaoming, Yan, Chunhong, Chen, Xiaoguang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anticarcinogenic activity Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Cancer therapy caspases Cell Line, Tumor Cell Proliferation - drug effects cell viability clinical trials Drug Screening Assays, Antitumor Female fluorescence Gastric cancer growth retardation heat shock proteins Hsp90 HSP90 Heat-Shock Proteins - antagonists & inhibitors Hsp90 inhibitor Humans Mice Mice, Nude Models, Molecular Molecular chaperone Neoplasm Transplantation oncogene proteins Proteasome Endopeptidase Complex - metabolism Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-raf - metabolism resorcinol Resorcinols - chemistry Resorcinols - pharmacology Signal Transduction stomach neoplasms Stomach Neoplasms - drug therapy Stomach Neoplasms - pathology toxicity Tumor Burden - drug effects weight loss
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