HOXB13 Mutation and Prostate Cancer: Studies of Siblings and Aggressive Disease

Recent work detected for the first time a high-risk prostate cancer mutation, in homeobox B13 (HOXB13) among European-Americans. We further evaluated this G84E missense mutation (rs138213197) in two genetic association studies of prostate cancer: a family-based study of brothers and a case-control s...

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Veröffentlicht in:	Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2013-04, Vol.22 (4), p.675-680
Hauptverfasser:	WITTE, John S, MEFFORD, Joel, PLUMMER, Sarah J, JINGHUA LIU, LONA CHENG, KLEIN, Eric A, RYBICKI, Benjamin A, CASEY, Graham
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Case-Control Studies Disease Progression DNA - genetics Genetic Predisposition to Disease Homeodomain Proteins - genetics Humans Male Medical sciences Middle Aged Mutation - genetics Neoplasm Grading Neoplasm Staging Nephrology. Urinary tract diseases Polymerase Chain Reaction Prognosis Prostate - pathology Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Risk Factors Siblings Tumors Tumors of the urinary system Urinary tract. Prostate gland
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