Factors affecting dense and alpha-granule secretion from electropermeabilized human platelets: Ca(2+)-independent actions of phorbol ester and GTP gamma S

Electropermeabilized human platelets containing 5-hydroxy[14C]tryptamine ([14C]5-HT) were suspended in a glutamate medium containing ATP and incubated for 10 min with (in various combinations) Ca2+ buffers, phorbol 12-myristate 13-acetate (PMA), guanine nucleotides, and thrombin. Release of [14C]5-H...

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Veröffentlicht in:	Cell regulation 1990-12, Vol.1 (13), p.1027-1041
Hauptverfasser:	Coorssen, J R, Davidson, M M, Haslam, R J
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Platelets - drug effects Blood Platelets - metabolism Blood Proteins - metabolism Calcium - metabolism Cytoplasmic Granules - secretion Guanine Nucleotides - pharmacology Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Humans Lysosomes - metabolism Myosins - metabolism Permeability Phorbol Esters - pharmacology Phosphatidylinositols - metabolism Phosphoproteins Phosphorylation Proteins - metabolism Thrombin - pharmacology Type C Phospholipases - metabolism
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