Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis

The receptor activator of NF-KB （RANK） and immunoreceptor tyrosine-based activation motif （ITAM）-containing adaptors are essential factors involved in regulating osteoclast formation and bone remodeling. Here, we identify early estrogen-induced gene 1 （EEIG1） as a novel RANK ligand （RANKL）-inducible...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell research 2013-04, Vol.23 (4), p.524-536
Hauptverfasser:	Choi, Han Kyoung, Kang, Hye Ri, Jung, Eutteum, Kim, Tae Eon, Lin, Jing Jing, Lee, Soo Young
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/815 631/80/86 692/698/690/292/797 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Biomedical and Life Sciences Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Bone Resorption - genetics Bone Resorption - metabolism Bone Resorption - pathology Carrier Proteins - genetics Carrier Proteins - metabolism Cell Biology Cell Differentiation Cell Line Estrogens Gene Expression Regulation - drug effects Humans Life Sciences Mice NF-κB NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism Original original-article Osteoclasts - cytology Osteoclasts - drug effects Osteoclasts - metabolism Peptides - pharmacology Phospholipase C gamma - genetics Phospholipase C gamma - metabolism Phosphorylation - drug effects Protein Binding Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proteins RANK RANK Ligand - genetics RANK Ligand - metabolism Receptor Activator of Nuclear Factor-kappa B - antagonists & inhibitors Receptor Activator of Nuclear Factor-kappa B - genetics Receptor Activator of Nuclear Factor-kappa B - metabolism Signal Transduction - drug effects 信令早期基因破骨细胞组件诱导基因雌激素
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!