NKT cell costimulation: experimental progress and therapeutic promise

Invariant natural killer T ( i NKT) cells are innate lymphocytes with unique specificity for glycolipid antigens and remarkable immunomodulatory properties. The role of costimulatory interactions in i NKT cell responses has recently come under scrutiny. Although i NKT cells and their prototype glyco...

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Veröffentlicht in:	Trends in molecular medicine 2011-02, Vol.17 (2), p.65-77
Hauptverfasser:	van den Heuvel, Marianne J, Garg, Nitan, Van Kaer, Luc, Haeryfar, S.M. Mansour
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation - genetics Antigens, Differentiation - immunology Cancer Clinical trials Costimulator galactosylceramide Gene Expression Regulation - immunology Glycolipids Humans Immunomodulation Immunotherapy Lymphocyte Activation - immunology Lymphocytes T Natural killer cells Natural Killer T-Cells - immunology Pathology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - immunology Reviews Signal Transduction - genetics Signal Transduction - immunology T-cell receptor
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