Growth hormone modulation of EGF-induced PI3K-Akt pathway in mice liver

The epidermal growth factor (EGF) activates the phosphatidylinositol 3-kinase (PI3K)-Akt cascade among other signaling pathways. This route is involved in cell proliferation and survival, therefore, its dysregulation can promote cancer. Considering the relevance of the PI3K-Akt signaling in cell sur...

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Veröffentlicht in:	Cellular signalling 2012-02, Vol.24 (2), p.514-523
Hauptverfasser:	Díaz, Ma. Eugenia, González, Lorena, Miquet, Johanna G., Martínez, Carolina S., Sotelo, Ana I., Bartke, Andrzej, Turyn, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Epidermal growth factor (EGF) Epidermal Growth Factor - genetics Epidermal Growth Factor - metabolism Gene Expression GH transgenic mice Grb2-associated binder-1 (Gab1) Growth hormone (GH) Growth Hormone - genetics Growth Hormone - metabolism Liver - cytology Liver - metabolism Mice Mice, Transgenic Phosphatidylinositol 3-Kinase - genetics Phosphatidylinositol 3-Kinase - metabolism Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation PI3K-Akt pathway Protein Binding Protein Phosphatase 2 - genetics Protein Phosphatase 2 - metabolism Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Pyruvate Dehydrogenase Acetyl-Transferring Kinase Serine - genetics Serine - metabolism Signal Transduction - genetics Threonine - genetics Threonine - metabolism TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism
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