Surgery in asymptomatic patients with colorectal cancer and unresectable liver metastases: the authors' experience
In asymptomatic patients with Stage IV colorectal cancer, the debate continues over the efficacy of primary resection compared to chemotherapy alone. The aim of this study was to define the optimal management for asymptomatic patients with colorectal cancer and unresectable liver metastases. Patient...
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| Veröffentlicht in: | OncoTargets and therapy 2013-01, Vol.6, p.267-272 |
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| creator | Boselli, Carlo Renzi, Claudio Gemini, Alessandro Castellani, Elisa Trastulli, Stefano Desiderio, Jacopo Corsi, Alessia Barberini, Francesco Cirocchi, Roberto Santoro, Alberto Parisi, Amilcare Redler, Adriano Noya, Giuseppe |
| description | In asymptomatic patients with Stage IV colorectal cancer, the debate continues over the efficacy of primary resection compared to chemotherapy alone. The aim of this study was to define the optimal management for asymptomatic patients with colorectal cancer and unresectable liver metastases.
Patients receiving elective surgery (n = 17) were compared to patients receiving chemotherapy only (n = 31). Data concerning patients' demographics, location of primary tumor, comorbidities, performance status, Child-Pugh score, extension of liver metastases, size of primary, and other secondary locations were collected.
Thirty-day mortality after chemotherapy was lower than that after surgical resection (19.3% versus 29.4%; not significant). In patients with >75% hepatic involvement, mortality at 1 month was higher after receiving surgical treatment than after chemotherapy alone (50% versus 25%). In patients with |
| doi_str_mv | 10.2147/OTT.S39448 |
| format | Article |
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Patients receiving elective surgery (n = 17) were compared to patients receiving chemotherapy only (n = 31). Data concerning patients' demographics, location of primary tumor, comorbidities, performance status, Child-Pugh score, extension of liver metastases, size of primary, and other secondary locations were collected.
Thirty-day mortality after chemotherapy was lower than that after surgical resection (19.3% versus 29.4%; not significant). In patients with >75% hepatic involvement, mortality at 1 month was higher after receiving surgical treatment than after chemotherapy alone (50% versus 25%). In patients with <75% hepatic involvement, 30-day mortality was similar in both groups (not significant). Thirty-day mortality in patients with Stage T3 was lower in those receiving chemotherapy (16.7% versus 30%; not significant). Overall survival was similar in both groups. The risk of all-cause death after elective surgery (2.1) was significantly higher than in patients receiving chemotherapy only (P = 0.035).
This study demonstrated that in palliative treatment of asymptomatic unresectable Stage IV colorectal cancer, the overall risk of death was significantly higher after elective surgery compared to patients receiving chemotherapy alone. However, in the literature, there is no substantial difference between these treatments. New studies are required to better evaluate outcomes.</description><identifier>ISSN: 1178-6930</identifier><identifier>EISSN: 1178-6930</identifier><identifier>DOI: 10.2147/OTT.S39448</identifier><identifier>PMID: 23569390</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>30-day mortality ; Cancer ; Cancer therapies ; Care and treatment ; Chemotherapy ; Colorectal cancer ; Excision (Surgery) ; Health aspects ; inoperable liver replacement ; large bowel ; Liver cancer ; Metastasis ; Mortality ; Original Research ; palliative surgery ; Surgery ; tumor</subject><ispartof>OncoTargets and therapy, 2013-01, Vol.6, p.267-272</ispartof><rights>COPYRIGHT 2013 Dove Medical Press Limited</rights><rights>2013. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Boselli et al, publisher and licensee Dove Medical Press Ltd 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c550t-252ea455a65954521ea01076f8e881e9fada129aff10b3942d3cff95271e32383</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615897/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615897/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3862,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23569390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boselli, Carlo</creatorcontrib><creatorcontrib>Renzi, Claudio</creatorcontrib><creatorcontrib>Gemini, Alessandro</creatorcontrib><creatorcontrib>Castellani, Elisa</creatorcontrib><creatorcontrib>Trastulli, Stefano</creatorcontrib><creatorcontrib>Desiderio, Jacopo</creatorcontrib><creatorcontrib>Corsi, Alessia</creatorcontrib><creatorcontrib>Barberini, Francesco</creatorcontrib><creatorcontrib>Cirocchi, Roberto</creatorcontrib><creatorcontrib>Santoro, Alberto</creatorcontrib><creatorcontrib>Parisi, Amilcare</creatorcontrib><creatorcontrib>Redler, Adriano</creatorcontrib><creatorcontrib>Noya, Giuseppe</creatorcontrib><title>Surgery in asymptomatic patients with colorectal cancer and unresectable liver metastases: the authors' experience</title><title>OncoTargets and therapy</title><addtitle>Onco Targets Ther</addtitle><description>In asymptomatic patients with Stage IV colorectal cancer, the debate continues over the efficacy of primary resection compared to chemotherapy alone. The aim of this study was to define the optimal management for asymptomatic patients with colorectal cancer and unresectable liver metastases.
Patients receiving elective surgery (n = 17) were compared to patients receiving chemotherapy only (n = 31). Data concerning patients' demographics, location of primary tumor, comorbidities, performance status, Child-Pugh score, extension of liver metastases, size of primary, and other secondary locations were collected.
Thirty-day mortality after chemotherapy was lower than that after surgical resection (19.3% versus 29.4%; not significant). In patients with >75% hepatic involvement, mortality at 1 month was higher after receiving surgical treatment than after chemotherapy alone (50% versus 25%). In patients with <75% hepatic involvement, 30-day mortality was similar in both groups (not significant). Thirty-day mortality in patients with Stage T3 was lower in those receiving chemotherapy (16.7% versus 30%; not significant). Overall survival was similar in both groups. The risk of all-cause death after elective surgery (2.1) was significantly higher than in patients receiving chemotherapy only (P = 0.035).
This study demonstrated that in palliative treatment of asymptomatic unresectable Stage IV colorectal cancer, the overall risk of death was significantly higher after elective surgery compared to patients receiving chemotherapy alone. However, in the literature, there is no substantial difference between these treatments. New studies are required to better evaluate outcomes.</description><subject>30-day mortality</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Colorectal cancer</subject><subject>Excision (Surgery)</subject><subject>Health aspects</subject><subject>inoperable liver replacement</subject><subject>large bowel</subject><subject>Liver cancer</subject><subject>Metastasis</subject><subject>Mortality</subject><subject>Original Research</subject><subject>palliative surgery</subject><subject>Surgery</subject><subject>tumor</subject><issn>1178-6930</issn><issn>1178-6930</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptUl1rFDEUHcRia_XFHyABQaWwaz4mM5k-CKVoKxT60PU5ZDN3dlIyyZhkVvffm2X7sSsmIQkn55zce7lF8Y7gOSVl_eV2sZjfsaYsxYvihJBazKqG4Zd79-PidYz3GFeVoOWr4pgynuEGnxThbgorCBtkHFJxM4zJDyoZjca8g0sR_TapR9pbH0AnZZFWTkNAyrVocgHiFl1aQNasMzxAUjEviOco9YDUlHof4icEf0YI2VHDm-KoUzbC24fztPj5_dvi8np2c3v14_LiZqY5x2lGOQVVcq4q3vCSUwIKE1xXnQAhCDSdahWhjeo6gpc5e9oy3XUNpzUBRplgp8XXne84LQdodc4mKCvHYAYVNtIrIw9fnOnlyq8lqwgXTZ0N8M6g9WsYc6rxQPyMaj9IQitMsuTzw5_B_5ogJjmYqMFa5cBPURJGOWOMljRTP_xDvfdTcLkikuZRi7ps8DNrpSxI4zqfQ9VbU3nBai4eI53_h5VnC4PR3kFnMn4g-Lgn6EHZ1Edvp2S8i4fEsx1RBx9jgO6pBATLbffJ3H1y132Z_H6_4k_Ux3ZjfwG1L9Yl</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Boselli, Carlo</creator><creator>Renzi, Claudio</creator><creator>Gemini, Alessandro</creator><creator>Castellani, Elisa</creator><creator>Trastulli, Stefano</creator><creator>Desiderio, Jacopo</creator><creator>Corsi, Alessia</creator><creator>Barberini, Francesco</creator><creator>Cirocchi, Roberto</creator><creator>Santoro, Alberto</creator><creator>Parisi, Amilcare</creator><creator>Redler, Adriano</creator><creator>Noya, Giuseppe</creator><general>Dove Medical Press Limited</general><general>Taylor & Francis Ltd</general><general>Dove Press</general><general>Dove Medical Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>Surgery in asymptomatic patients with colorectal cancer and unresectable liver metastases: the authors' experience</title><author>Boselli, Carlo ; 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The aim of this study was to define the optimal management for asymptomatic patients with colorectal cancer and unresectable liver metastases.
Patients receiving elective surgery (n = 17) were compared to patients receiving chemotherapy only (n = 31). Data concerning patients' demographics, location of primary tumor, comorbidities, performance status, Child-Pugh score, extension of liver metastases, size of primary, and other secondary locations were collected.
Thirty-day mortality after chemotherapy was lower than that after surgical resection (19.3% versus 29.4%; not significant). In patients with >75% hepatic involvement, mortality at 1 month was higher after receiving surgical treatment than after chemotherapy alone (50% versus 25%). In patients with <75% hepatic involvement, 30-day mortality was similar in both groups (not significant). Thirty-day mortality in patients with Stage T3 was lower in those receiving chemotherapy (16.7% versus 30%; not significant). Overall survival was similar in both groups. The risk of all-cause death after elective surgery (2.1) was significantly higher than in patients receiving chemotherapy only (P = 0.035).
This study demonstrated that in palliative treatment of asymptomatic unresectable Stage IV colorectal cancer, the overall risk of death was significantly higher after elective surgery compared to patients receiving chemotherapy alone. However, in the literature, there is no substantial difference between these treatments. New studies are required to better evaluate outcomes.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>23569390</pmid><doi>10.2147/OTT.S39448</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Taylor & Francis Open Access; DOVE Medical Press Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | 30-day mortality Cancer Cancer therapies Care and treatment Chemotherapy Colorectal cancer Excision (Surgery) Health aspects inoperable liver replacement large bowel Liver cancer Metastasis Mortality Original Research palliative surgery Surgery tumor |
| title | Surgery in asymptomatic patients with colorectal cancer and unresectable liver metastases: the authors' experience |
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