Protective effect of edaravone for tourniquet-induced ischemia-reperfusion injury on skeletal muscle in murine hindlimb

Studies have shown that ischemia-reperfusion (I/R) produces free radicals leading to lipid peroxidation and damage to skeletal muscle. The purposes of this study were 1) to assess the histological findings of gastrocnemius muscle (GC) and tibialis anterior muscle (TA) in I/R injury model mice, 2) to...

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Veröffentlicht in:	BMC musculoskeletal disorders 2013-03, Vol.14 (1), p.113-113, Article 113
Hauptverfasser:	Hori, Kazuichiro, Tsujii, Masaya, Iino, Takahiro, Satonaka, Haruhiko, Uemura, Takeshi, Akeda, Koji, Hasegawa, Masahiro, Uchida, Atsumasa, Sudo, Akihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal experimentation Animals Antioxidants Antipyrine - analogs & derivatives Antipyrine - pharmacology Antipyrine - therapeutic use Care and treatment Complications and side effects Free Radical Scavengers - pharmacology Free Radical Scavengers - therapeutic use Free radicals Free radicals (Chemistry) Health aspects Hindlimb - blood supply Hindlimb - drug effects Hindlimb - pathology Lipid peroxidation Male Mice Mice, Inbred C57BL Muscle, Skeletal - blood supply Muscle, Skeletal - drug effects Muscle, Skeletal - pathology Muscles Muscular system Musculoskeletal diseases Neuroprotective agents Nitric oxide Patient outcomes Proteins Reperfusion injury Reperfusion Injury - pathology Reperfusion Injury - prevention & control Rodents Tourniquets - adverse effects
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