Effect of ethanolic extract of Ecballium elaterium against Staphylococcus aureus and Candida albicans
Objective:To evaluate the antimicrobial activity of ethanolic extract of Ecballium elaterium(E. elaterium)fruits alone against Staphylococcus aureus(S.aureus) strains and Candida albicans(C.albicans)strains,or in combination with penicillin against Staphylococcus areus strains. Methods:Evaluation of...
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| Veröffentlicht in: | Asian Pacific journal of tropical biomedicine 2011-12, Vol.1 (6), p.456-460 |
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| creator | Adwan, Ghaleb Salameh, Yousef Adwan, Kamel |
| description | Objective:To evaluate the antimicrobial activity of ethanolic extract of Ecballium elaterium(E. elaterium)fruits alone against Staphylococcus aureus(S.aureus) strains and Candida albicans(C.albicans)strains,or in combination with penicillin against Staphylococcus areus strains. Methods:Evaluation of the antimicrobial activity or synergy interaction was carried out using microdilution method.Results:The results showed that ethanolic extract of E.elaterium fruits has antimicrobial activity against methicillin resistant S.aureus(MRSA),methicillin sensitive S. aureus(MSSA) and C.albicans.This extract showed a significant decrease in minimum inhibitory concentrations(MIC)of penicillin against both MRSA and MSSA strains.Fractional inhibitory concentration index(FIC)between penicillin and ethanolic extract of E.elaterium fruits against these test strains was less than 0.5.Conclusions:This study suggests that ethanolic extract of E.elaterium fruits has antimicrobial activity against S.aureus and C.albicans and there is a possibility of concurrent use of penicillin and E.elaterium extract in combination in the treatment of infections caused by MRSA and MSSA strains.A wider study is needed to identify the effective components,the mode of action and the possible toxic effect in vivo of these ingredients. |
| doi_str_mv | 10.1016/S2221-1691(11)60100-7 |
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Methods:Evaluation of the antimicrobial activity or synergy interaction was carried out using microdilution method.Results:The results showed that ethanolic extract of E.elaterium fruits has antimicrobial activity against methicillin resistant S.aureus(MRSA),methicillin sensitive S. aureus(MSSA) and C.albicans.This extract showed a significant decrease in minimum inhibitory concentrations(MIC)of penicillin against both MRSA and MSSA strains.Fractional inhibitory concentration index(FIC)between penicillin and ethanolic extract of E.elaterium fruits against these test strains was less than 0.5.Conclusions:This study suggests that ethanolic extract of E.elaterium fruits has antimicrobial activity against S.aureus and C.albicans and there is a possibility of concurrent use of penicillin and E.elaterium extract in combination in the treatment of infections caused by MRSA and MSSA strains.A wider study is needed to identify the effective components,the mode of action and the possible toxic effect in vivo of these ingredients.</description><identifier>ISSN: 2221-1691</identifier><identifier>EISSN: 2588-9222</identifier><identifier>DOI: 10.1016/S2221-1691(11)60100-7</identifier><identifier>PMID: 23569813</identifier><language>eng</language><publisher>China: Elsevier B.V</publisher><subject>albicans ; Anti-Infective Agents - isolation & purification ; Anti-Infective Agents - pharmacology ; Candida ; Candida albicans ; Candida albicans - drug effects ; Cucurbitaceae - chemistry ; Drug Synergism ; Ecballium ; Ecballium elaterium ; elaterium ; extract ; Humans ; Medicinal ; Medicinal plant ; Microbial Sensitivity Tests ; MRSA ; Original ; Penicillins - pharmacology ; plant ; Plant extract ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plants, Medicinal - chemistry ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Synergism</subject><ispartof>Asian Pacific journal of tropical biomedicine, 2011-12, Vol.1 (6), p.456-460</ispartof><rights>2011 Asian Pacific Tropical Biomedical Magazine</rights><rights>2011 by the Asian Pacific Journal of Tropical Biomedicine. All rights reserved. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4798-b909b88e9a79d0a481eb46c83454f6c599deb1700591c9637917779c400bbe243</citedby><cites>FETCH-LOGICAL-c4798-b909b88e9a79d0a481eb46c83454f6c599deb1700591c9637917779c400bbe243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/71871X/71871X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614208/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614208/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23569813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adwan, Ghaleb</creatorcontrib><creatorcontrib>Salameh, Yousef</creatorcontrib><creatorcontrib>Adwan, Kamel</creatorcontrib><title>Effect of ethanolic extract of Ecballium elaterium against Staphylococcus aureus and Candida albicans</title><title>Asian Pacific journal of tropical biomedicine</title><addtitle>Asian Pacific Journal of Tropical Biomedicine</addtitle><description>Objective:To evaluate the antimicrobial activity of ethanolic extract of Ecballium elaterium(E. elaterium)fruits alone against Staphylococcus aureus(S.aureus) strains and Candida albicans(C.albicans)strains,or in combination with penicillin against Staphylococcus areus strains. Methods:Evaluation of the antimicrobial activity or synergy interaction was carried out using microdilution method.Results:The results showed that ethanolic extract of E.elaterium fruits has antimicrobial activity against methicillin resistant S.aureus(MRSA),methicillin sensitive S. aureus(MSSA) and C.albicans.This extract showed a significant decrease in minimum inhibitory concentrations(MIC)of penicillin against both MRSA and MSSA strains.Fractional inhibitory concentration index(FIC)between penicillin and ethanolic extract of E.elaterium fruits against these test strains was less than 0.5.Conclusions:This study suggests that ethanolic extract of E.elaterium fruits has antimicrobial activity against S.aureus and C.albicans and there is a possibility of concurrent use of penicillin and E.elaterium extract in combination in the treatment of infections caused by MRSA and MSSA strains.A wider study is needed to identify the effective components,the mode of action and the possible toxic effect in vivo of these ingredients.</description><subject>albicans</subject><subject>Anti-Infective Agents - isolation & purification</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Candida</subject><subject>Candida albicans</subject><subject>Candida albicans - drug effects</subject><subject>Cucurbitaceae - chemistry</subject><subject>Drug Synergism</subject><subject>Ecballium</subject><subject>Ecballium elaterium</subject><subject>elaterium</subject><subject>extract</subject><subject>Humans</subject><subject>Medicinal</subject><subject>Medicinal plant</subject><subject>Microbial Sensitivity Tests</subject><subject>MRSA</subject><subject>Original</subject><subject>Penicillins - pharmacology</subject><subject>plant</subject><subject>Plant extract</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal - chemistry</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Synergism</subject><issn>2221-1691</issn><issn>2588-9222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcFu1DAQjRAVrUo_ARSJA-UQ8NiOY19A1WqhlSr1UDhbjjPZNfLaWzup6N_j7W6rcsIHz2jmzZtnv6p6B-QzEBBfbiml0IBQcA7wSRAgpOleVSe0lbJRpfm65E-Q4-os59-kHEEobfmb6piyVigJ7KTC5Tiineo41jitTYje2Rr_TMnsi0vbG-_dvKnRmwnTLjMr40Ke6tvJbNcPPtpo7ZxrMyfchTDUi3K5wdTG986akN9WR6PxGc8O8bT69X35c3HZXN_8uFpcXDeWd0o2vSKqlxKV6dRADJeAPRdWMt7yUdhWqQF76AhpFVglWKeg6zplOSF9j5Sz0-rrnnc79xscLIbyEK-3yW1MetDROP1vJ7i1XsV7zQRwSmQh-HggSPFuxjzpjcsWvTcB45y1IpwrKhkUZLtH2hRzTjg-bwGidybpR5P0zgENoB9N0l2Ze_9S4vPUkyUF8G0PwPJR9w6TztZhsDi4VJzSQ3T_XfHhIG0dw-rOhdULbYQRJttWsL-H8K2z</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Adwan, Ghaleb</creator><creator>Salameh, Yousef</creator><creator>Adwan, Kamel</creator><general>Elsevier B.V</general><general>Asian Pacific Tropical Medicine Press</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>M7N</scope><scope>5PM</scope></search><sort><creationdate>20111201</creationdate><title>Effect of ethanolic extract of Ecballium elaterium against Staphylococcus aureus and Candida albicans</title><author>Adwan, Ghaleb ; Salameh, Yousef ; Adwan, Kamel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4798-b909b88e9a79d0a481eb46c83454f6c599deb1700591c9637917779c400bbe243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>albicans</topic><topic>Anti-Infective Agents - isolation & purification</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Candida</topic><topic>Candida albicans</topic><topic>Candida albicans - drug effects</topic><topic>Cucurbitaceae - chemistry</topic><topic>Drug Synergism</topic><topic>Ecballium</topic><topic>Ecballium elaterium</topic><topic>elaterium</topic><topic>extract</topic><topic>Humans</topic><topic>Medicinal</topic><topic>Medicinal plant</topic><topic>Microbial Sensitivity Tests</topic><topic>MRSA</topic><topic>Original</topic><topic>Penicillins - pharmacology</topic><topic>plant</topic><topic>Plant extract</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants, Medicinal - chemistry</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Synergism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adwan, Ghaleb</creatorcontrib><creatorcontrib>Salameh, Yousef</creatorcontrib><creatorcontrib>Adwan, Kamel</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Asian Pacific journal of tropical biomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adwan, Ghaleb</au><au>Salameh, Yousef</au><au>Adwan, Kamel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of ethanolic extract of Ecballium elaterium against Staphylococcus aureus and Candida albicans</atitle><jtitle>Asian Pacific journal of tropical biomedicine</jtitle><addtitle>Asian Pacific Journal of Tropical Biomedicine</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>1</volume><issue>6</issue><spage>456</spage><epage>460</epage><pages>456-460</pages><issn>2221-1691</issn><eissn>2588-9222</eissn><abstract>Objective:To evaluate the antimicrobial activity of ethanolic extract of Ecballium elaterium(E. elaterium)fruits alone against Staphylococcus aureus(S.aureus) strains and Candida albicans(C.albicans)strains,or in combination with penicillin against Staphylococcus areus strains. Methods:Evaluation of the antimicrobial activity or synergy interaction was carried out using microdilution method.Results:The results showed that ethanolic extract of E.elaterium fruits has antimicrobial activity against methicillin resistant S.aureus(MRSA),methicillin sensitive S. aureus(MSSA) and C.albicans.This extract showed a significant decrease in minimum inhibitory concentrations(MIC)of penicillin against both MRSA and MSSA strains.Fractional inhibitory concentration index(FIC)between penicillin and ethanolic extract of E.elaterium fruits against these test strains was less than 0.5.Conclusions:This study suggests that ethanolic extract of E.elaterium fruits has antimicrobial activity against S.aureus and C.albicans and there is a possibility of concurrent use of penicillin and E.elaterium extract in combination in the treatment of infections caused by MRSA and MSSA strains.A wider study is needed to identify the effective components,the mode of action and the possible toxic effect in vivo of these ingredients.</abstract><cop>China</cop><pub>Elsevier B.V</pub><pmid>23569813</pmid><doi>10.1016/S2221-1691(11)60100-7</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | albicans Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Candida Candida albicans Candida albicans - drug effects Cucurbitaceae - chemistry Drug Synergism Ecballium Ecballium elaterium elaterium extract Humans Medicinal Medicinal plant Microbial Sensitivity Tests MRSA Original Penicillins - pharmacology plant Plant extract Plant Extracts - isolation & purification Plant Extracts - pharmacology Plants, Medicinal - chemistry Staphylococcus aureus Staphylococcus aureus - drug effects Synergism |
| title | Effect of ethanolic extract of Ecballium elaterium against Staphylococcus aureus and Candida albicans |
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