The thiazole derivative CPTH6 impairs autophagy

We have previously demonstrated that the thiazole derivative 3-methylcyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl]hydrazone (CPTH6) induces apoptosis and cell cycle arrest in human leukemia cells. The aim of this study was to evaluate whether CPTH6 is able to affect autophagy. By using several...

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Veröffentlicht in:	Cell death & disease 2013-03, Vol.4 (3), p.e524-e524
Hauptverfasser:	Ragazzoni, Y, Desideri, M, Gabellini, C, De Luca, T, Carradori, S, Secci, D, Nescatelli, R, Candiloro, A, Condello, M, Meschini, S, Del Bufalo, D, Trisciuoglio, D
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/436 631/80/39 692/699/67 Acetyltransferases - antagonists & inhibitors Acetyltransferases - genetics Acetyltransferases - metabolism Adaptor Proteins, Signal Transducing - metabolism Antibodies Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Autophagy - drug effects Autophagy-Related Protein 7 Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell Line, Tumor HL-60 Cells Humans Immunology Intracellular Signaling Peptides and Proteins Life Sciences Microtubule-Associated Proteins - metabolism Original original-article Proteins - metabolism RNA Interference RNA, Small Interfering - metabolism Sequestosome-1 Protein Thiazoles - chemistry Thiazoles - pharmacology Ubiquitin-Activating Enzymes - metabolism
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