The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation

The establishment of the epigenetic mark H4K20me1 (monomethylation of H4K20) by PR-Set7 during G2/M directly impacts S-phase progression and genome stability. However, the mechanisms involved in the regulation of this event are not well understood. Here we show that SirT2 regulates H4K20me1 depositi...

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Veröffentlicht in:	Genes & development 2013-03, Vol.27 (6), p.639-653
Hauptverfasser:	Serrano, Lourdes, Martínez-Redondo, Paloma, Marazuela-Duque, Anna, Vazquez, Berta N, Dooley, Scott J, Voigt, Philipp, Beck, David B, Kane-Goldsmith, Noriko, Tong, Qiang, Rabanal, Rosa M, Fondevila, Dolors, Muñoz, Purificación, Krüger, Marcus, Tischfield, Jay A, Vaquero, Alejandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Amino Acid Sequence Animals Cell Cycle - physiology Cell Transformation, Neoplastic - genetics Chromatin - metabolism DNA Damage - genetics Gene Knockout Techniques Genomic Instability HeLa Cells Histone-Lysine N-Methyltransferase - metabolism Histones - metabolism Humans M Phase Cell Cycle Checkpoints - physiology Methylation Mice Mice, Knockout Mitosis Protein Binding Research Paper Sirtuin 2 - genetics Sirtuin 2 - metabolism
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