Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling

The transcription factor Ikaros regulates the development of hematopoietic cells. Ikaros-deficient animals fail to develop B cells and display a T-cell malignancy, which is correlated with altered Notch signaling. Recently, loss of Ikaros was associated with progression of myeloproliferative neoplas...

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Veröffentlicht in:	Blood 2013-03, Vol.121 (13), p.2440-2451
Hauptverfasser:	Malinge, Sébastien, Thiollier, Clarisse, Chlon, Timothy M., Doré, Louis C., Diebold, Lauren, Bluteau, Olivier, Mabialah, Vinciane, Vainchenker, William, Dessen, Philippe, Winandy, Susan, Mercher, Thomas, Crispino, John D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - genetics Cell Differentiation - immunology Cell Proliferation Cells, Cultured Down-Regulation - genetics Embryo, Mammalian GATA1 Transcription Factor - metabolism Gene Expression Regulation, Developmental Hematopoiesis and Stem Cells Ikaros Transcription Factor - genetics Ikaros Transcription Factor - metabolism Ikaros Transcription Factor - physiology Megakaryocytes - metabolism Megakaryocytes - physiology Mice Mice, Knockout Models, Biological Protein Binding - genetics Protein Binding - physiology Receptors, Notch - metabolism Signal Transduction - genetics Signal Transduction - physiology Thrombopoiesis - genetics
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