The role and mechanism-of-action of Sema3E and Plexin-D1 in vascular and neural development

► Sema3E can bind and signal directly with Plexin-D1, independently of neuropilins. ► Sema3E-Plexin-D1 regulates multiple aspects of neural and vascular development. ► Sema3E–Plexin-D1 controls developmental processes via different mechanisms of actions. ► Different downstream effectors will also re...

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Veröffentlicht in:	Seminars in cell & developmental biology 2013-03, Vol.24 (3), p.156-162
Hauptverfasser:	Oh, Won-Jong, Gu, Chenghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion Molecules - metabolism Central Nervous System - blood supply Central Nervous System - metabolism Guidance Humans Neovascularization, Pathologic Neovascularization, Physiologic Nerve Tissue Proteins - metabolism Neural development Plexin-D1 Plexins Semaphorin3E Semaphorins Semaphorins - genetics Semaphorins - metabolism Signaling Vascular development Vascular Endothelial Growth Factor A - metabolism
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