Association of Pro12Ala polymorphism in peroxisome proliferator activated receptor gamma with proliferative diabetic retinopathy
The association of non-synonymous substitution polymorphism rs1801282 (c.34C>G, p.Pro12Ala) in exon 4 of the peroxisome proliferator activated receptor gamma gene with diabetic retinopathy (DR) has been reported inconsistently. Therefore, the purpose of the present study was to understand the pop...
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| Veröffentlicht in: | Molecular vision 2013-03, Vol.19, p.710-717 |
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| creator | Tariq, Khadija Malik, Saira Bano Ali, Syeda Hafiza Benish Maqsood, Sundas Ejaz Azam, Aisha Muslim, Irfan Khan, Muhammad Shakil Azam, Maleeha Waheed, Nadia Khalida Qamar, Raheel |
| description | The association of non-synonymous substitution polymorphism rs1801282 (c.34C>G, p.Pro12Ala) in exon 4 of the peroxisome proliferator activated receptor gamma gene with diabetic retinopathy (DR) has been reported inconsistently. Therefore, the purpose of the present study was to understand the population-specific role of the Pro12Ala polymorphism in DR susceptibility in Pakistani subjects.
A total of 180 subjects with DR, 193 subjects with type 2 diabetes mellitus (T2DM) with no diabetic retinopathy, and 200 healthy normoglycemic non-retinopathic Pakistani individuals were genotyped for the rs1801282 (c.34C>G) polymorphism using polymerase chain reaction-restriction fragment length polymorphism.
We found the individuals with T2DM carrying 12Ala were at a reduced risk of developing DR (odds ratio [OR]=0.53; 95% confidence interval [CI]=0.33-0.87). Upon stratified analysis regarding disease severity, we observed this protective effect was confined to proliferative DR (OR=0.4; 95% CI=0.2-0.8) with non-significant effects on the susceptibility of non-proliferative DR (OR=0.67; 95% CI=0.37-1.19).
We report a protective role of the 12Ala polymorphism against proliferative DR in individuals with T2DM in Pakistan. |
| format | Article |
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A total of 180 subjects with DR, 193 subjects with type 2 diabetes mellitus (T2DM) with no diabetic retinopathy, and 200 healthy normoglycemic non-retinopathic Pakistani individuals were genotyped for the rs1801282 (c.34C>G) polymorphism using polymerase chain reaction-restriction fragment length polymorphism.
We found the individuals with T2DM carrying 12Ala were at a reduced risk of developing DR (odds ratio [OR]=0.53; 95% confidence interval [CI]=0.33-0.87). Upon stratified analysis regarding disease severity, we observed this protective effect was confined to proliferative DR (OR=0.4; 95% CI=0.2-0.8) with non-significant effects on the susceptibility of non-proliferative DR (OR=0.67; 95% CI=0.37-1.19).
We report a protective role of the 12Ala polymorphism against proliferative DR in individuals with T2DM in Pakistan.</description><identifier>EISSN: 1090-0535</identifier><identifier>PMID: 23559865</identifier><language>eng</language><publisher>United States: Molecular Vision</publisher><subject>Adult ; Amino Acid Substitution - genetics ; Case-Control Studies ; Diabetic Retinopathy - genetics ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide - genetics ; PPAR gamma - genetics ; Risk Factors</subject><ispartof>Molecular vision, 2013-03, Vol.19, p.710-717</ispartof><rights>Copyright © 2013 Molecular Vision. 2013 Molecular Vision</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611930/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611930/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23559865$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tariq, Khadija</creatorcontrib><creatorcontrib>Malik, Saira Bano</creatorcontrib><creatorcontrib>Ali, Syeda Hafiza Benish</creatorcontrib><creatorcontrib>Maqsood, Sundas Ejaz</creatorcontrib><creatorcontrib>Azam, Aisha</creatorcontrib><creatorcontrib>Muslim, Irfan</creatorcontrib><creatorcontrib>Khan, Muhammad Shakil</creatorcontrib><creatorcontrib>Azam, Maleeha</creatorcontrib><creatorcontrib>Waheed, Nadia Khalida</creatorcontrib><creatorcontrib>Qamar, Raheel</creatorcontrib><title>Association of Pro12Ala polymorphism in peroxisome proliferator activated receptor gamma with proliferative diabetic retinopathy</title><title>Molecular vision</title><addtitle>Mol Vis</addtitle><description>The association of non-synonymous substitution polymorphism rs1801282 (c.34C>G, p.Pro12Ala) in exon 4 of the peroxisome proliferator activated receptor gamma gene with diabetic retinopathy (DR) has been reported inconsistently. Therefore, the purpose of the present study was to understand the population-specific role of the Pro12Ala polymorphism in DR susceptibility in Pakistani subjects.
A total of 180 subjects with DR, 193 subjects with type 2 diabetes mellitus (T2DM) with no diabetic retinopathy, and 200 healthy normoglycemic non-retinopathic Pakistani individuals were genotyped for the rs1801282 (c.34C>G) polymorphism using polymerase chain reaction-restriction fragment length polymorphism.
We found the individuals with T2DM carrying 12Ala were at a reduced risk of developing DR (odds ratio [OR]=0.53; 95% confidence interval [CI]=0.33-0.87). Upon stratified analysis regarding disease severity, we observed this protective effect was confined to proliferative DR (OR=0.4; 95% CI=0.2-0.8) with non-significant effects on the susceptibility of non-proliferative DR (OR=0.67; 95% CI=0.37-1.19).
We report a protective role of the 12Ala polymorphism against proliferative DR in individuals with T2DM in Pakistan.</description><subject>Adult</subject><subject>Amino Acid Substitution - genetics</subject><subject>Case-Control Studies</subject><subject>Diabetic Retinopathy - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>PPAR gamma - genetics</subject><subject>Risk Factors</subject><issn>1090-0535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtKxDAYhYsgzjj6CpIXKCTN5LYRhsEbCLrQdfmb_J1G2iakcXR2ProjXhhXB87lW5yjYs6ooSUVXMyK02l6obRiYqlOilnFhTBainnxsZqmYD1kH0YSWvKYAqtWPZAY-t0QUuz8NBA_kogpvPspDEhiCr1vMUEOiYDNfgsZHUloMX5ZGxgGIG8-dwdVv0XiPDSYvd1Xsx9DhNztzorjFvoJz390UTxfXz2tb8v7h5u79eq-jJWUuVQWZOMsMCec5kpxxV1jlg6Zc6rVUmpUTFswVCjTamqsRmmxkS2CYgb5orj85sbXZkBnccwJ-jomP0Da1QF8_T8ZfVdvwrbmkjHD6R5wcQj4W_5-yT8Byal17A</recordid><startdate>20130321</startdate><enddate>20130321</enddate><creator>Tariq, Khadija</creator><creator>Malik, Saira Bano</creator><creator>Ali, Syeda Hafiza Benish</creator><creator>Maqsood, Sundas Ejaz</creator><creator>Azam, Aisha</creator><creator>Muslim, Irfan</creator><creator>Khan, Muhammad Shakil</creator><creator>Azam, Maleeha</creator><creator>Waheed, Nadia Khalida</creator><creator>Qamar, Raheel</creator><general>Molecular Vision</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>20130321</creationdate><title>Association of Pro12Ala polymorphism in peroxisome proliferator activated receptor gamma with proliferative diabetic retinopathy</title><author>Tariq, Khadija ; Malik, Saira Bano ; Ali, Syeda Hafiza Benish ; Maqsood, Sundas Ejaz ; Azam, Aisha ; Muslim, Irfan ; Khan, Muhammad Shakil ; Azam, Maleeha ; Waheed, Nadia Khalida ; Qamar, Raheel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-7ca6bdca1d5d8377373db94de1dd7f8668e718ca90579f809c8e6ceb6fea719e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Amino Acid Substitution - genetics</topic><topic>Case-Control Studies</topic><topic>Diabetic Retinopathy - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>PPAR gamma - genetics</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tariq, Khadija</creatorcontrib><creatorcontrib>Malik, Saira Bano</creatorcontrib><creatorcontrib>Ali, Syeda Hafiza Benish</creatorcontrib><creatorcontrib>Maqsood, Sundas Ejaz</creatorcontrib><creatorcontrib>Azam, Aisha</creatorcontrib><creatorcontrib>Muslim, Irfan</creatorcontrib><creatorcontrib>Khan, Muhammad Shakil</creatorcontrib><creatorcontrib>Azam, Maleeha</creatorcontrib><creatorcontrib>Waheed, Nadia Khalida</creatorcontrib><creatorcontrib>Qamar, Raheel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular vision</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tariq, Khadija</au><au>Malik, Saira Bano</au><au>Ali, Syeda Hafiza Benish</au><au>Maqsood, Sundas Ejaz</au><au>Azam, Aisha</au><au>Muslim, Irfan</au><au>Khan, Muhammad Shakil</au><au>Azam, Maleeha</au><au>Waheed, Nadia Khalida</au><au>Qamar, Raheel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Pro12Ala polymorphism in peroxisome proliferator activated receptor gamma with proliferative diabetic retinopathy</atitle><jtitle>Molecular vision</jtitle><addtitle>Mol Vis</addtitle><date>2013-03-21</date><risdate>2013</risdate><volume>19</volume><spage>710</spage><epage>717</epage><pages>710-717</pages><eissn>1090-0535</eissn><abstract>The association of non-synonymous substitution polymorphism rs1801282 (c.34C>G, p.Pro12Ala) in exon 4 of the peroxisome proliferator activated receptor gamma gene with diabetic retinopathy (DR) has been reported inconsistently. Therefore, the purpose of the present study was to understand the population-specific role of the Pro12Ala polymorphism in DR susceptibility in Pakistani subjects.
A total of 180 subjects with DR, 193 subjects with type 2 diabetes mellitus (T2DM) with no diabetic retinopathy, and 200 healthy normoglycemic non-retinopathic Pakistani individuals were genotyped for the rs1801282 (c.34C>G) polymorphism using polymerase chain reaction-restriction fragment length polymorphism.
We found the individuals with T2DM carrying 12Ala were at a reduced risk of developing DR (odds ratio [OR]=0.53; 95% confidence interval [CI]=0.33-0.87). Upon stratified analysis regarding disease severity, we observed this protective effect was confined to proliferative DR (OR=0.4; 95% CI=0.2-0.8) with non-significant effects on the susceptibility of non-proliferative DR (OR=0.67; 95% CI=0.37-1.19).
We report a protective role of the 12Ala polymorphism against proliferative DR in individuals with T2DM in Pakistan.</abstract><cop>United States</cop><pub>Molecular Vision</pub><pmid>23559865</pmid><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Amino Acid Substitution - genetics Case-Control Studies Diabetic Retinopathy - genetics Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Humans Male Middle Aged Polymorphism, Single Nucleotide - genetics PPAR gamma - genetics Risk Factors |
| title | Association of Pro12Ala polymorphism in peroxisome proliferator activated receptor gamma with proliferative diabetic retinopathy |
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