Comparison of BMP-2 and combined IGF-I/TGF-ss1 application in a sheep cervical spine fusion model

Growth factors have proven to promote spine fusion. However, no comparative evaluation of growth factors in spinal fusion has yet been performed. The purpose of this study was to compare the efficacy and safety of combined IGF-I and TGF-ss1 application with BMP-2 application and autologous cancellou...

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Veröffentlicht in:	European spine journal 2002-10, Vol.11 (5), p.482-493
Hauptverfasser:	Kandziora, F, Pflugmacher, R, Scholz, M, Knispel, C, Hiller, T, Schollmeier, G, Bail, H, Schmidmaier, G, Duda, G, Raschke, M, Haas, N P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Cell Count Body Weight - drug effects Body Weight - physiology Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins - pharmacology Bone Morphogenetic Proteins - therapeutic use Bone Transplantation - methods Bone Transplantation - trends Cervical Vertebrae - drug effects Cervical Vertebrae - growth & development Cervical Vertebrae - surgery Drug Interactions - physiology Drug Therapy, Combination Female Insulin-Like Growth Factor I - pharmacology Insulin-Like Growth Factor I - therapeutic use Internal Fixators - trends Models, Animal Original Osteogenesis - drug effects Osteogenesis - physiology Postoperative Complications - etiology Postoperative Complications - pathology Postoperative Complications - physiopathology Range of Motion, Articular - drug effects Range of Motion, Articular - physiology Sheep Spinal Fusion - methods Spinal Fusion - trends Tomography, X-Ray Computed Transforming Growth Factor beta Transforming Growth Factors - pharmacology Transforming Growth Factors - therapeutic use Transplantation, Autologous - methods Transplantation, Autologous - trends Treatment Outcome Wound Healing - drug effects Wound Healing - physiology
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