Baculovirus as versatile vectors for protein expression in insect and mammalian cells
Today, many thousands of recombinant proteins, ranging from cytosolic enzymes to membrane-bound proteins, have been successfully produced in baculovirus-infected insect cells. Yet, in addition to its value in producing recombinant proteins in insect cells and larvae, this viral vector system continu...
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| Veröffentlicht in: | Nature biotechnology 2005-05, Vol.23 (5), p.567-575 |
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| creator | Kost, Thomas A Condreay, J Patrick Jarvis, Donald L |
| description | Today, many thousands of recombinant proteins, ranging from cytosolic enzymes to membrane-bound proteins, have been successfully produced in baculovirus-infected insect cells. Yet, in addition to its value in producing recombinant proteins in insect cells and larvae, this viral vector system continues to evolve in new and unexpected ways. This is exemplified by the development of engineered insect cell lines to mimic mammalian cell glycosylation of expressed proteins, baculovirus display strategies and the application of the virus as a mammalian-cell gene delivery vector. Novel vector design and cell engineering approaches will serve to further enhance the value of baculovirus technology. |
| doi_str_mv | 10.1038/nbt1095 |
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Yet, in addition to its value in producing recombinant proteins in insect cells and larvae, this viral vector system continues to evolve in new and unexpected ways. This is exemplified by the development of engineered insect cell lines to mimic mammalian cell glycosylation of expressed proteins, baculovirus display strategies and the application of the virus as a mammalian-cell gene delivery vector. Novel vector design and cell engineering approaches will serve to further enhance the value of baculovirus technology.</description><identifier>ISSN: 1087-0156</identifier><identifier>EISSN: 1546-1696</identifier><identifier>DOI: 10.1038/nbt1095</identifier><identifier>PMID: 15877075</identifier><identifier>CODEN: NABIF9</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Agriculture ; Animals ; Baculoviridae - genetics ; Baculovirus ; Bioinformatics ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedical Engineering/Biotechnology ; Biomedicine ; Biotechnology ; Biotechnology - methods ; Biotechnology - trends ; Cells ; Cloning ; Fundamental and applied biological sciences. Psychology ; Genetic engineering ; Genetic Enhancement - methods ; Genetic technics ; Genetic Vectors - genetics ; Humans ; Insecta ; Insects ; Kinases ; Larvae ; Life Sciences ; Mammals ; Methods. Procedures. Technologies ; Peptides ; Protein Engineering - methods ; Protein Engineering - trends ; Protein expression ; Proteins ; Recombinant Proteins - biosynthesis ; review-article ; Transfection - methods ; Vectors (cloning, transfer, expression). Insertion sequences and transposons ; Viruses</subject><ispartof>Nature biotechnology, 2005-05, Vol.23 (5), p.567-575</ispartof><rights>Springer Nature America, Inc. 2005</rights><rights>2005 INIST-CNRS</rights><rights>COPYRIGHT 2005 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2005</rights><rights>Nature Publishing Group 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c654t-f5fb034cfc3fb45aacfbca1424892427531e58c3d9cf8f102b33d7b970e7fca73</citedby><cites>FETCH-LOGICAL-c654t-f5fb034cfc3fb45aacfbca1424892427531e58c3d9cf8f102b33d7b970e7fca73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nbt1095$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nbt1095$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,2725,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16758706$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15877075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kost, Thomas A</creatorcontrib><creatorcontrib>Condreay, J Patrick</creatorcontrib><creatorcontrib>Jarvis, Donald L</creatorcontrib><title>Baculovirus as versatile vectors for protein expression in insect and mammalian cells</title><title>Nature biotechnology</title><addtitle>Nat Biotechnol</addtitle><addtitle>Nat Biotechnol</addtitle><description>Today, many thousands of recombinant proteins, ranging from cytosolic enzymes to membrane-bound proteins, have been successfully produced in baculovirus-infected insect cells. Yet, in addition to its value in producing recombinant proteins in insect cells and larvae, this viral vector system continues to evolve in new and unexpected ways. This is exemplified by the development of engineered insect cell lines to mimic mammalian cell glycosylation of expressed proteins, baculovirus display strategies and the application of the virus as a mammalian-cell gene delivery vector. Novel vector design and cell engineering approaches will serve to further enhance the value of baculovirus technology.</description><subject>Agriculture</subject><subject>Animals</subject><subject>Baculoviridae - genetics</subject><subject>Baculovirus</subject><subject>Bioinformatics</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering/Biotechnology</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Biotechnology - methods</subject><subject>Biotechnology - trends</subject><subject>Cells</subject><subject>Cloning</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic engineering</subject><subject>Genetic Enhancement - methods</subject><subject>Genetic technics</subject><subject>Genetic Vectors - genetics</subject><subject>Humans</subject><subject>Insecta</subject><subject>Insects</subject><subject>Kinases</subject><subject>Larvae</subject><subject>Life Sciences</subject><subject>Mammals</subject><subject>Methods. Procedures. Technologies</subject><subject>Peptides</subject><subject>Protein Engineering - methods</subject><subject>Protein Engineering - trends</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Recombinant Proteins - biosynthesis</subject><subject>review-article</subject><subject>Transfection - methods</subject><subject>Vectors (cloning, transfer, expression). 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| ispartof | Nature biotechnology, 2005-05, Vol.23 (5), p.567-575 |
| issn | 1087-0156 1546-1696 |
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| subjects | Agriculture Animals Baculoviridae - genetics Baculovirus Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Biotechnology - methods Biotechnology - trends Cells Cloning Fundamental and applied biological sciences. Psychology Genetic engineering Genetic Enhancement - methods Genetic technics Genetic Vectors - genetics Humans Insecta Insects Kinases Larvae Life Sciences Mammals Methods. Procedures. Technologies Peptides Protein Engineering - methods Protein Engineering - trends Protein expression Proteins Recombinant Proteins - biosynthesis review-article Transfection - methods Vectors (cloning, transfer, expression). Insertion sequences and transposons Viruses |
| title | Baculovirus as versatile vectors for protein expression in insect and mammalian cells |
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