Caspase-1-induced pyroptotic cell death

Programmed cell death is a necessary part of development and tissue homeostasis enabling the removal of unwanted cells. In the setting of infectious disease, cells that have been commandeered by microbial pathogens become detrimental to the host. When macrophages and dendritic cells are compromised...

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Veröffentlicht in:	Immunological reviews 2011-09, Vol.243 (1), p.206-214
Hauptverfasser:	Miao, Edward A., Rajan, Jayant V., Aderem, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Calcium-Binding Proteins - metabolism CARD Signaling Adaptor Proteins - metabolism Carrier Proteins - metabolism Caspase 1 - immunology Caspase 1 - metabolism Caspase-1 Cell Death - immunology Dendritic cells Dendritic Cells - immunology Dendritic Cells - microbiology Dendritic Cells - virology DNA-Binding Proteins Homeostasis Humans Infection - immunology Infection Control Infectious diseases Inflammasomes - immunology Inflammation Interleukin 1 Interleukin 18 Interleukin-18 - immunology Interleukin-1beta - immunology Macrophages Macrophages - immunology Macrophages - microbiology Macrophages - virology monocytes/macrophages Necrosis NLR Family, Pyrin Domain-Containing 3 Protein Nuclear Proteins - metabolism Pathogens pattern recognition receptors pyroptosis Signal Transduction - immunology
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