TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1

There is growing interest in identifying regulators of autophagy. The molecular mechanism underlying transforming growth factor-β activated kinase 1 (TAK1)-induced autophagy is poorly understood. We found that TAK1 inhibits p70 S6 kinase1 (S6K1) phosphorylation by interfering interaction of raptor w...

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Veröffentlicht in:	Scientific reports 2013-03, Vol.3 (1), p.1561-1561, Article 1561
Hauptverfasser:	Shin, Ju Hyun, Min, Sang-Hyun, Kim, Seong-Jin, Kim, Young-Il, Park, Junsoo, Lee, Heung Kyu, Yoo, Ook Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80 631/80/82 631/80/82/39 631/80/82/39/2346 Animals Apoptosis Autophagy Autophagy - physiology Cell death Cytotoxicity Drosophila melanogaster Drosophila Proteins - metabolism Eye HEK293 Cells Humanities and Social Sciences Humans Intracellular Signaling Peptides and Proteins - metabolism L-Lactate dehydrogenase Lactic acid Mammalian cells MAP Kinase Kinase Kinases - biosynthesis MAP Kinase Kinase Kinases - metabolism Mortality multidisciplinary p70 S6 kinase Phagocytosis Phosphorylation Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors Ribosomal Protein S6 Kinases, 70-kDa - metabolism Science Starvation - physiopathology TAK1 protein Transforming growth factor Transforming growth factor-b
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