Transferrin Receptor-Targeted Lipid Nanoparticles for Delivery of an Antisense Oligodeoxyribonucleotide against Bcl-2

Antisense oligonucleotide G3139-mediated down-regulation of Bcl-2 is a potential strategy for overcoming chemoresistance in leukemia. However, the limited efficacy shown in recent clinical trials calls attention to the need for further development of novel and more efficient delivery systems. In ord...

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Veröffentlicht in:	Molecular pharmaceutics 2009-01, Vol.6 (1), p.221-230
Hauptverfasser:	Yang, Xiaojuan, Koh, Chee Guan, Liu, Shujun, Pan, Xiaogang, Santhanam, Ramasamy, Yu, Bo, Peng, Yong, Pang, Jiuxia, Golan, Sharon, Talmon, Yeshayahu, Jin, Yan, Muthusamy, Natarajan, Byrd, John C, Chan, Kenneth K, Lee, L. James, Marcucci, Guido, Lee, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell Line, Tumor Colloids Cryoelectron Microscopy Down-Regulation Drug Delivery Systems Humans Lipids - chemistry Microscopy, Electron, Transmission Nanoparticles - chemistry Nanoparticles - ultrastructure Oligodeoxyribonucleotides, Antisense - chemistry Oligodeoxyribonucleotides, Antisense - genetics Oligodeoxyribonucleotides, Antisense - metabolism Particle Size Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Receptors, Transferrin - chemistry Receptors, Transferrin - metabolism
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