Coordination of the Vernalization Response through a VIN3 and FLC Gene Family Regulatory Network in Arabidopsis
Vernalization is an environmentally induced epigenetic switch in which winter cold triggers epigenetic silencing of floral repressors and thus provides competence to flower in spring. Vernalization triggers the recruitment of chromatin-modifying complexes to a clade of flowering repressors that are...
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| Veröffentlicht in: | The Plant cell 2013-02, Vol.25 (2), p.454-469 |
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| creator | Kim, Dong-Hwan Sung, Sibum |
| description | Vernalization is an environmentally induced epigenetic switch in which winter cold triggers epigenetic silencing of floral repressors and thus provides competence to flower in spring. Vernalization triggers the recruitment of chromatin-modifying complexes to a clade of flowering repressors that are epigenetically silenced via chromatin modifications. In Arabidopsis thaliana, VERNALIZATION INSENSITIVE3 (VIN3) and its related plant homeodomain finger proteins act together with Polycomb Repressive Complex 2 to increase repressive histone marks at floral repressor loci, including FLOWERING LOCUS C (FLC) and its related genes, by vernalization. Here, we show that VIN3 family of proteins nonredundantly functions to repress different subsets of the FLC gene family during the course of vernalization. Each VIN3 family protein binds to modified histone peptides in vitro and directly associates with specific sets of FLC gene family chromatins in vivo to mediate epigenetic silencing. In addition, members of the FLC gene family are also differentially regulated during the course of vernalization to mediate proper vernalization response. Our results show that these two gene families cooperated during the course of evolution to ensure proper vernalization response through epigenetic changes. |
| doi_str_mv | 10.1105/tpc.112.104760 |
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Vernalization triggers the recruitment of chromatin-modifying complexes to a clade of flowering repressors that are epigenetically silenced via chromatin modifications. In Arabidopsis thaliana, VERNALIZATION INSENSITIVE3 (VIN3) and its related plant homeodomain finger proteins act together with Polycomb Repressive Complex 2 to increase repressive histone marks at floral repressor loci, including FLOWERING LOCUS C (FLC) and its related genes, by vernalization. Here, we show that VIN3 family of proteins nonredundantly functions to repress different subsets of the FLC gene family during the course of vernalization. Each VIN3 family protein binds to modified histone peptides in vitro and directly associates with specific sets of FLC gene family chromatins in vivo to mediate epigenetic silencing. In addition, members of the FLC gene family are also differentially regulated during the course of vernalization to mediate proper vernalization response. Our results show that these two gene families cooperated during the course of evolution to ensure proper vernalization response through epigenetic changes.</description><identifier>ISSN: 1040-4651</identifier><identifier>EISSN: 1532-298X</identifier><identifier>DOI: 10.1105/tpc.112.104760</identifier><identifier>PMID: 23417034</identifier><language>eng</language><publisher>United States: American Society of Plant Biologists</publisher><subject>Amino Acid Sequence ; Arabidopsis - physiology ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - metabolism ; Chromatin ; Chromatin - genetics ; Chromatin - metabolism ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Epigenesis, Genetic ; Family members ; Flowering ; Flowers - physiology ; Gene Expression Regulation, Plant ; Gene Regulatory Networks ; Genes ; Histones ; Histones - metabolism ; MADS Domain Proteins - genetics ; MADS Domain Proteins - metabolism ; Messenger RNA ; Molecular Sequence Data ; Multigene Family ; Mutation ; Plant cells ; Plants ; Plants, Genetically Modified ; Polycomb Repressive Complex 2 - genetics ; Polycomb Repressive Complex 2 - metabolism ; Repression ; Repressor Proteins - genetics ; Repressor Proteins - metabolism ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Vernalization</subject><ispartof>The Plant cell, 2013-02, Vol.25 (2), p.454-469</ispartof><rights>2013 American Society of Plant Biologists</rights><rights>2013 American Society of Plant Biologists. All rights reserved. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-b4116c3485f76d30b125bf9d5013aa42003be45470b2f5d4ae5a333566d40a653</citedby><cites>FETCH-LOGICAL-c478t-b4116c3485f76d30b125bf9d5013aa42003be45470b2f5d4ae5a333566d40a653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41812281$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41812281$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23417034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Dong-Hwan</creatorcontrib><creatorcontrib>Sung, Sibum</creatorcontrib><title>Coordination of the Vernalization Response through a VIN3 and FLC Gene Family Regulatory Network in Arabidopsis</title><title>The Plant cell</title><addtitle>Plant Cell</addtitle><description>Vernalization is an environmentally induced epigenetic switch in which winter cold triggers epigenetic silencing of floral repressors and thus provides competence to flower in spring. Vernalization triggers the recruitment of chromatin-modifying complexes to a clade of flowering repressors that are epigenetically silenced via chromatin modifications. In Arabidopsis thaliana, VERNALIZATION INSENSITIVE3 (VIN3) and its related plant homeodomain finger proteins act together with Polycomb Repressive Complex 2 to increase repressive histone marks at floral repressor loci, including FLOWERING LOCUS C (FLC) and its related genes, by vernalization. Here, we show that VIN3 family of proteins nonredundantly functions to repress different subsets of the FLC gene family during the course of vernalization. Each VIN3 family protein binds to modified histone peptides in vitro and directly associates with specific sets of FLC gene family chromatins in vivo to mediate epigenetic silencing. In addition, members of the FLC gene family are also differentially regulated during the course of vernalization to mediate proper vernalization response. Our results show that these two gene families cooperated during the course of evolution to ensure proper vernalization response through epigenetic changes.</description><subject>Amino Acid Sequence</subject><subject>Arabidopsis - physiology</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Chromatin</subject><subject>Chromatin - genetics</subject><subject>Chromatin - metabolism</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Epigenesis, Genetic</subject><subject>Family members</subject><subject>Flowering</subject><subject>Flowers - physiology</subject><subject>Gene Expression Regulation, Plant</subject><subject>Gene Regulatory Networks</subject><subject>Genes</subject><subject>Histones</subject><subject>Histones - metabolism</subject><subject>MADS Domain Proteins - genetics</subject><subject>MADS Domain Proteins - metabolism</subject><subject>Messenger RNA</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family</subject><subject>Mutation</subject><subject>Plant cells</subject><subject>Plants</subject><subject>Plants, Genetically Modified</subject><subject>Polycomb Repressive Complex 2 - genetics</subject><subject>Polycomb Repressive Complex 2 - metabolism</subject><subject>Repression</subject><subject>Repressor Proteins - genetics</subject><subject>Repressor Proteins - metabolism</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Vernalization</subject><issn>1040-4651</issn><issn>1532-298X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtv1DAUhS1ERR-wZQfykk2m9_qVzAapGjGl0qhICCp2lpM4My4ZO9hJq-mvxyhlBCsf-Xz32LqHkLcIC0SQl-PQZMEWCKJU8IKcoeSsYMvqx8usQUAhlMRTcp7SPQBgictX5JRxgSVwcUbCKoTYOm9GFzwNHR13lt7Z6E3vnubLrzYNwSebrRim7Y4aendzy6nxLV1vVvTaekvXZu_6Q2a3U2_GEA_01o6PIf6kztOraGrXhiG59JqcdKZP9s3zeUG-rz99W30uNl-ub1ZXm6IRZTUWtUBUDReV7ErVcqiRybpbthKQGyMYAK-tkKKEmnWyFcZKwzmXSrUCjJL8gnycc4ep3tu2sX6MptdDdHsTDzoYp_93vNvpbXjQXEFVlpgDPjwHxPBrsmnUe5ca2_fG2zAljZwh50pJldHFjDYxpBRtd3wGQf9pSeeWsmB6bikPvP_3c0f8by0ZeDcD9ynv8ugLrJCxCvlv0TeYEw</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Kim, Dong-Hwan</creator><creator>Sung, Sibum</creator><general>American Society of Plant Biologists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130201</creationdate><title>Coordination of the Vernalization Response through a VIN3 and FLC Gene Family Regulatory Network in Arabidopsis</title><author>Kim, Dong-Hwan ; Sung, Sibum</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-b4116c3485f76d30b125bf9d5013aa42003be45470b2f5d4ae5a333566d40a653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Amino Acid Sequence</topic><topic>Arabidopsis - physiology</topic><topic>Arabidopsis Proteins - genetics</topic><topic>Arabidopsis Proteins - metabolism</topic><topic>Chromatin</topic><topic>Chromatin - genetics</topic><topic>Chromatin - metabolism</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Epigenesis, Genetic</topic><topic>Family members</topic><topic>Flowering</topic><topic>Flowers - physiology</topic><topic>Gene Expression Regulation, Plant</topic><topic>Gene Regulatory Networks</topic><topic>Genes</topic><topic>Histones</topic><topic>Histones - metabolism</topic><topic>MADS Domain Proteins - genetics</topic><topic>MADS Domain Proteins - metabolism</topic><topic>Messenger RNA</topic><topic>Molecular Sequence Data</topic><topic>Multigene Family</topic><topic>Mutation</topic><topic>Plant cells</topic><topic>Plants</topic><topic>Plants, Genetically Modified</topic><topic>Polycomb Repressive Complex 2 - genetics</topic><topic>Polycomb Repressive Complex 2 - metabolism</topic><topic>Repression</topic><topic>Repressor Proteins - genetics</topic><topic>Repressor Proteins - metabolism</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Vernalization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Dong-Hwan</creatorcontrib><creatorcontrib>Sung, Sibum</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Plant cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Dong-Hwan</au><au>Sung, Sibum</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coordination of the Vernalization Response through a VIN3 and FLC Gene Family Regulatory Network in Arabidopsis</atitle><jtitle>The Plant cell</jtitle><addtitle>Plant Cell</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>25</volume><issue>2</issue><spage>454</spage><epage>469</epage><pages>454-469</pages><issn>1040-4651</issn><eissn>1532-298X</eissn><abstract>Vernalization is an environmentally induced epigenetic switch in which winter cold triggers epigenetic silencing of floral repressors and thus provides competence to flower in spring. Vernalization triggers the recruitment of chromatin-modifying complexes to a clade of flowering repressors that are epigenetically silenced via chromatin modifications. In Arabidopsis thaliana, VERNALIZATION INSENSITIVE3 (VIN3) and its related plant homeodomain finger proteins act together with Polycomb Repressive Complex 2 to increase repressive histone marks at floral repressor loci, including FLOWERING LOCUS C (FLC) and its related genes, by vernalization. Here, we show that VIN3 family of proteins nonredundantly functions to repress different subsets of the FLC gene family during the course of vernalization. Each VIN3 family protein binds to modified histone peptides in vitro and directly associates with specific sets of FLC gene family chromatins in vivo to mediate epigenetic silencing. In addition, members of the FLC gene family are also differentially regulated during the course of vernalization to mediate proper vernalization response. Our results show that these two gene families cooperated during the course of evolution to ensure proper vernalization response through epigenetic changes.</abstract><cop>United States</cop><pub>American Society of Plant Biologists</pub><pmid>23417034</pmid><doi>10.1105/tpc.112.104760</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acid Sequence Arabidopsis - physiology Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Chromatin Chromatin - genetics Chromatin - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epigenesis, Genetic Family members Flowering Flowers - physiology Gene Expression Regulation, Plant Gene Regulatory Networks Genes Histones Histones - metabolism MADS Domain Proteins - genetics MADS Domain Proteins - metabolism Messenger RNA Molecular Sequence Data Multigene Family Mutation Plant cells Plants Plants, Genetically Modified Polycomb Repressive Complex 2 - genetics Polycomb Repressive Complex 2 - metabolism Repression Repressor Proteins - genetics Repressor Proteins - metabolism Transcription Factors - genetics Transcription Factors - metabolism Vernalization |
| title | Coordination of the Vernalization Response through a VIN3 and FLC Gene Family Regulatory Network in Arabidopsis |
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