Role of lymphoscintigraphy and sentinel lymph node biopsy in the management of pediatric melanoma and sarcoma
Purpose The purpose of this study was to describe the use of lymphoscintigraphy and sentinel lymph-node biopsy (SLNB) for the management of children with melanoma and sarcomas. We report the experience of two children’s hospitals that utilize this technique to identify sentinel lymph nodes for lymph...
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| Veröffentlicht in: | Pediatric surgery international 2012-06, Vol.28 (6), p.571-578 |
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| creator | Parida, Lalit Morrisson, Griffin T. Shammas, Amer Hossain, A. K. M. Moinul McCarville, M. Beth Gerstle, J. Ted Charron, Martin Rao, Bhaskar N. Shulkin, Barry L. |
| description | Purpose
The purpose of this study was to describe the use of lymphoscintigraphy and sentinel lymph-node biopsy (SLNB) for the management of children with melanoma and sarcomas. We report the experience of two children’s hospitals that utilize this technique to identify sentinel lymph nodes for lymph-node biopsy and dissection.
Methods
We identified 56 patients (median age 10.8 years) who underwent 58 lymphoscintigraphy procedures. There were 33 patients with melanoma and melanocytic lesions, and 23 with sarcomas.
Results
Of 58 lymphoscintigraphy procedures, sentinel lymph nodes were identified in 52 (90% success rate). Using the combination of intraoperative blue dye injection and lymphoscintigraphy, the success rate was 95% (55/58). Metastatic disease was found in 14 sentinel lymph nodes (13 patients with melanoma and melanocytic lesions, and 1 patient with rhabdomyosarcoma).
Conclusion
We have found that lymphoscintigraphy with SLNB is an effective method to identify patients who may benefit from more extensive lymph-node dissection and to identify those patients who are unlikely to benefit from further lymph-node exploration. |
| doi_str_mv | 10.1007/s00383-012-3066-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3608674</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1017987751</sourcerecordid><originalsourceid>FETCH-LOGICAL-c536t-5e1d2aaba33957f3de69a3ce18b2fa514083b0f2baa7a0d8a2b15392feca4d2e3</originalsourceid><addsrcrecordid>eNp1kU9r3DAQxUVpaTZpP0AvRdBLL271x7KtS6GEtikECiU5i7E83lWwJFfyhuy3jxanIS3kJIn5zZt5eoS84-wTZ6z9nBmTnawYF5VkTVPdvSAbXsu20h2XL8mG8VZXTKruhJzmfMMY62SjX5MTIZRoVK02xP-OE9I40ung513M1oXFbRPMuwOFMNCM5R1wWus0xAFp7-KcD9QFuuyQegiwRV-4o8yMg4MlOUs9ThCih1UGki33N-TVCFPGtw_nGbn-_u3q_KK6_PXj5_nXy8oq2SyVQj4IgB6k1Kod5YCNBmmRd70YQfG6-OjZKHqAFtjQgei5klqMaKEeBMoz8mXVnfe9x8GW5RJMZk7OQzqYCM78WwluZ7bx1siGdU1bF4GPDwIp_tljXox32eJULGHcZ8OPX9u1reIF_fAfehP3KRR7hdJKaV7rtlB8pWyKOSccH5fhzBzDNGuYpoRpjmGau9Lz_qmLx46_6RVArEAupbDF9HT0c6r3Suqt3w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1095591497</pqid></control><display><type>article</type><title>Role of lymphoscintigraphy and sentinel lymph node biopsy in the management of pediatric melanoma and sarcoma</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Parida, Lalit ; Morrisson, Griffin T. ; Shammas, Amer ; Hossain, A. K. M. Moinul ; McCarville, M. Beth ; Gerstle, J. Ted ; Charron, Martin ; Rao, Bhaskar N. ; Shulkin, Barry L.</creator><creatorcontrib>Parida, Lalit ; Morrisson, Griffin T. ; Shammas, Amer ; Hossain, A. K. M. Moinul ; McCarville, M. Beth ; Gerstle, J. Ted ; Charron, Martin ; Rao, Bhaskar N. ; Shulkin, Barry L.</creatorcontrib><description>Purpose
The purpose of this study was to describe the use of lymphoscintigraphy and sentinel lymph-node biopsy (SLNB) for the management of children with melanoma and sarcomas. We report the experience of two children’s hospitals that utilize this technique to identify sentinel lymph nodes for lymph-node biopsy and dissection.
Methods
We identified 56 patients (median age 10.8 years) who underwent 58 lymphoscintigraphy procedures. There were 33 patients with melanoma and melanocytic lesions, and 23 with sarcomas.
Results
Of 58 lymphoscintigraphy procedures, sentinel lymph nodes were identified in 52 (90% success rate). Using the combination of intraoperative blue dye injection and lymphoscintigraphy, the success rate was 95% (55/58). Metastatic disease was found in 14 sentinel lymph nodes (13 patients with melanoma and melanocytic lesions, and 1 patient with rhabdomyosarcoma).
Conclusion
We have found that lymphoscintigraphy with SLNB is an effective method to identify patients who may benefit from more extensive lymph-node dissection and to identify those patients who are unlikely to benefit from further lymph-node exploration.</description><identifier>ISSN: 0179-0358</identifier><identifier>EISSN: 1437-9813</identifier><identifier>DOI: 10.1007/s00383-012-3066-x</identifier><identifier>PMID: 22526545</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Lymphoscintigraphy ; Male ; Medicine ; Medicine & Public Health ; Melanoma - diagnostic imaging ; Melanoma - pathology ; Original Article ; Pediatric Surgery ; Pediatrics ; Retrospective Studies ; Sarcoma - diagnostic imaging ; Sarcoma - pathology ; Sentinel Lymph Node Biopsy ; Skin Neoplasms - diagnostic imaging ; Skin Neoplasms - pathology ; Soft Tissue Neoplasms - diagnostic imaging ; Soft Tissue Neoplasms - pathology ; Surgery</subject><ispartof>Pediatric surgery international, 2012-06, Vol.28 (6), p.571-578</ispartof><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-5e1d2aaba33957f3de69a3ce18b2fa514083b0f2baa7a0d8a2b15392feca4d2e3</citedby><cites>FETCH-LOGICAL-c536t-5e1d2aaba33957f3de69a3ce18b2fa514083b0f2baa7a0d8a2b15392feca4d2e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00383-012-3066-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00383-012-3066-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22526545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parida, Lalit</creatorcontrib><creatorcontrib>Morrisson, Griffin T.</creatorcontrib><creatorcontrib>Shammas, Amer</creatorcontrib><creatorcontrib>Hossain, A. K. M. Moinul</creatorcontrib><creatorcontrib>McCarville, M. Beth</creatorcontrib><creatorcontrib>Gerstle, J. Ted</creatorcontrib><creatorcontrib>Charron, Martin</creatorcontrib><creatorcontrib>Rao, Bhaskar N.</creatorcontrib><creatorcontrib>Shulkin, Barry L.</creatorcontrib><title>Role of lymphoscintigraphy and sentinel lymph node biopsy in the management of pediatric melanoma and sarcoma</title><title>Pediatric surgery international</title><addtitle>Pediatr Surg Int</addtitle><addtitle>Pediatr Surg Int</addtitle><description>Purpose
The purpose of this study was to describe the use of lymphoscintigraphy and sentinel lymph-node biopsy (SLNB) for the management of children with melanoma and sarcomas. We report the experience of two children’s hospitals that utilize this technique to identify sentinel lymph nodes for lymph-node biopsy and dissection.
Methods
We identified 56 patients (median age 10.8 years) who underwent 58 lymphoscintigraphy procedures. There were 33 patients with melanoma and melanocytic lesions, and 23 with sarcomas.
Results
Of 58 lymphoscintigraphy procedures, sentinel lymph nodes were identified in 52 (90% success rate). Using the combination of intraoperative blue dye injection and lymphoscintigraphy, the success rate was 95% (55/58). Metastatic disease was found in 14 sentinel lymph nodes (13 patients with melanoma and melanocytic lesions, and 1 patient with rhabdomyosarcoma).
Conclusion
We have found that lymphoscintigraphy with SLNB is an effective method to identify patients who may benefit from more extensive lymph-node dissection and to identify those patients who are unlikely to benefit from further lymph-node exploration.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Lymphoscintigraphy</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Melanoma - diagnostic imaging</subject><subject>Melanoma - pathology</subject><subject>Original Article</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Retrospective Studies</subject><subject>Sarcoma - diagnostic imaging</subject><subject>Sarcoma - pathology</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>Skin Neoplasms - diagnostic imaging</subject><subject>Skin Neoplasms - pathology</subject><subject>Soft Tissue Neoplasms - diagnostic imaging</subject><subject>Soft Tissue Neoplasms - pathology</subject><subject>Surgery</subject><issn>0179-0358</issn><issn>1437-9813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU9r3DAQxUVpaTZpP0AvRdBLL271x7KtS6GEtikECiU5i7E83lWwJFfyhuy3jxanIS3kJIn5zZt5eoS84-wTZ6z9nBmTnawYF5VkTVPdvSAbXsu20h2XL8mG8VZXTKruhJzmfMMY62SjX5MTIZRoVK02xP-OE9I40ung513M1oXFbRPMuwOFMNCM5R1wWus0xAFp7-KcD9QFuuyQegiwRV-4o8yMg4MlOUs9ThCih1UGki33N-TVCFPGtw_nGbn-_u3q_KK6_PXj5_nXy8oq2SyVQj4IgB6k1Kod5YCNBmmRd70YQfG6-OjZKHqAFtjQgei5klqMaKEeBMoz8mXVnfe9x8GW5RJMZk7OQzqYCM78WwluZ7bx1siGdU1bF4GPDwIp_tljXox32eJULGHcZ8OPX9u1reIF_fAfehP3KRR7hdJKaV7rtlB8pWyKOSccH5fhzBzDNGuYpoRpjmGau9Lz_qmLx46_6RVArEAupbDF9HT0c6r3Suqt3w</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Parida, Lalit</creator><creator>Morrisson, Griffin T.</creator><creator>Shammas, Amer</creator><creator>Hossain, A. K. M. Moinul</creator><creator>McCarville, M. Beth</creator><creator>Gerstle, J. 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K. M. Moinul ; McCarville, M. Beth ; Gerstle, J. Ted ; Charron, Martin ; Rao, Bhaskar N. ; Shulkin, Barry L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-5e1d2aaba33957f3de69a3ce18b2fa514083b0f2baa7a0d8a2b15392feca4d2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Lymphoscintigraphy</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Melanoma - diagnostic imaging</topic><topic>Melanoma - pathology</topic><topic>Original Article</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Retrospective Studies</topic><topic>Sarcoma - diagnostic imaging</topic><topic>Sarcoma - pathology</topic><topic>Sentinel Lymph Node Biopsy</topic><topic>Skin Neoplasms - diagnostic imaging</topic><topic>Skin Neoplasms - pathology</topic><topic>Soft Tissue Neoplasms - diagnostic imaging</topic><topic>Soft Tissue Neoplasms - pathology</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parida, Lalit</creatorcontrib><creatorcontrib>Morrisson, Griffin T.</creatorcontrib><creatorcontrib>Shammas, Amer</creatorcontrib><creatorcontrib>Hossain, A. K. M. Moinul</creatorcontrib><creatorcontrib>McCarville, M. Beth</creatorcontrib><creatorcontrib>Gerstle, J. Ted</creatorcontrib><creatorcontrib>Charron, Martin</creatorcontrib><creatorcontrib>Rao, Bhaskar N.</creatorcontrib><creatorcontrib>Shulkin, Barry L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric surgery international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parida, Lalit</au><au>Morrisson, Griffin T.</au><au>Shammas, Amer</au><au>Hossain, A. K. M. Moinul</au><au>McCarville, M. Beth</au><au>Gerstle, J. Ted</au><au>Charron, Martin</au><au>Rao, Bhaskar N.</au><au>Shulkin, Barry L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of lymphoscintigraphy and sentinel lymph node biopsy in the management of pediatric melanoma and sarcoma</atitle><jtitle>Pediatric surgery international</jtitle><stitle>Pediatr Surg Int</stitle><addtitle>Pediatr Surg Int</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>28</volume><issue>6</issue><spage>571</spage><epage>578</epage><pages>571-578</pages><issn>0179-0358</issn><eissn>1437-9813</eissn><abstract>Purpose
The purpose of this study was to describe the use of lymphoscintigraphy and sentinel lymph-node biopsy (SLNB) for the management of children with melanoma and sarcomas. We report the experience of two children’s hospitals that utilize this technique to identify sentinel lymph nodes for lymph-node biopsy and dissection.
Methods
We identified 56 patients (median age 10.8 years) who underwent 58 lymphoscintigraphy procedures. There were 33 patients with melanoma and melanocytic lesions, and 23 with sarcomas.
Results
Of 58 lymphoscintigraphy procedures, sentinel lymph nodes were identified in 52 (90% success rate). Using the combination of intraoperative blue dye injection and lymphoscintigraphy, the success rate was 95% (55/58). Metastatic disease was found in 14 sentinel lymph nodes (13 patients with melanoma and melanocytic lesions, and 1 patient with rhabdomyosarcoma).
Conclusion
We have found that lymphoscintigraphy with SLNB is an effective method to identify patients who may benefit from more extensive lymph-node dissection and to identify those patients who are unlikely to benefit from further lymph-node exploration.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22526545</pmid><doi>10.1007/s00383-012-3066-x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Pediatric surgery international, 2012-06, Vol.28 (6), p.571-578 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Child Child, Preschool Female Humans Infant Lymphoscintigraphy Male Medicine Medicine & Public Health Melanoma - diagnostic imaging Melanoma - pathology Original Article Pediatric Surgery Pediatrics Retrospective Studies Sarcoma - diagnostic imaging Sarcoma - pathology Sentinel Lymph Node Biopsy Skin Neoplasms - diagnostic imaging Skin Neoplasms - pathology Soft Tissue Neoplasms - diagnostic imaging Soft Tissue Neoplasms - pathology Surgery |
| title | Role of lymphoscintigraphy and sentinel lymph node biopsy in the management of pediatric melanoma and sarcoma |
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