The effect of microvascular pattern alterations on network resistance in spontaneously hypertensive rats
Structural microvascular rarefaction, defined by a loss of vessels, is a common characteristic of hypertension and has been associated with elevated microvascular resistance. However, determining the causal relationship between microvascular network structure and resistance requires a consideration...
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| Veröffentlicht in: | Medical & biological engineering & computing 2012-06, Vol.50 (6), p.585-593 |
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| description | Structural microvascular rarefaction, defined by a loss of vessels, is a common characteristic of hypertension and has been associated with elevated microvascular resistance. However, determining the causal relationship between microvascular network structure and resistance requires a consideration of all pattern changes throughout a network. The objectives of this study were to determine whether microvascular rarefaction is associated with other network pattern alterations and to evaluate whether pattern alterations in hypertension necessarily contribute to increased microvascular resistance. Mesenteric tissues from age-matched (15–16 weeks) male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were harvested and immunolabeled for PECAM. SHR networks displayed a decreased microvascular area, arteriolar-venular (AV) length, number of AV branches, and number of capillary segments. In addition, SHR networks displayed increased AV connections per network compared to WKY networks. Based on network geometries, resistance per network was calculated using a computational model. For simulations with equal vessel diameter and with relative diameters based on reported intravital measurements, SHR microvascular network resistance was not elevated compared to the WKY level. Our results suggest that microvascular pattern alterations associated with hypertension are more complex than vessel loss, and that these combined alterations do not necessarily lead to elevated resistance. |
| doi_str_mv | 10.1007/s11517-012-0912-x |
| format | Article |
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However, determining the causal relationship between microvascular network structure and resistance requires a consideration of all pattern changes throughout a network. The objectives of this study were to determine whether microvascular rarefaction is associated with other network pattern alterations and to evaluate whether pattern alterations in hypertension necessarily contribute to increased microvascular resistance. Mesenteric tissues from age-matched (15–16 weeks) male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were harvested and immunolabeled for PECAM. SHR networks displayed a decreased microvascular area, arteriolar-venular (AV) length, number of AV branches, and number of capillary segments. In addition, SHR networks displayed increased AV connections per network compared to WKY networks. Based on network geometries, resistance per network was calculated using a computational model. For simulations with equal vessel diameter and with relative diameters based on reported intravital measurements, SHR microvascular network resistance was not elevated compared to the WKY level. Our results suggest that microvascular pattern alterations associated with hypertension are more complex than vessel loss, and that these combined alterations do not necessarily lead to elevated resistance.</description><identifier>ISSN: 0140-0118</identifier><identifier>EISSN: 1741-0444</identifier><identifier>DOI: 10.1007/s11517-012-0912-x</identifier><identifier>PMID: 22562369</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Animals ; Antibodies ; Biomedical and Life Sciences ; Biomedical engineering ; Biomedical Engineering and Bioengineering ; Biomedicine ; Blood pressure ; Blood vessels ; Computer Applications ; Human Physiology ; Hypertension ; Hypertension - pathology ; Hypertension - physiopathology ; Imaging ; Laboratories ; Male ; Medical imaging ; Mesentery ; Microcirculation - physiology ; Microvessels - pathology ; Morphology ; Original Article ; Radiology ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Rodents ; Splanchnic Circulation - physiology ; Studies ; Vascular Resistance - physiology</subject><ispartof>Medical & biological engineering & computing, 2012-06, Vol.50 (6), p.585-593</ispartof><rights>International Federation for Medical and Biological Engineering 2012</rights><rights>International Federation for Medical and Biological Engineering 2012 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c569t-9ac0d6f9f6016be8b9102627cd9e286cd0e009b9315df2a2c28ea083d3e10ec43</citedby><cites>FETCH-LOGICAL-c569t-9ac0d6f9f6016be8b9102627cd9e286cd0e009b9315df2a2c28ea083d3e10ec43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11517-012-0912-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11517-012-0912-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,777,781,882,27906,27907,41470,42539,51301</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22562369$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Ming</creatorcontrib><creatorcontrib>Murfee, Walter L.</creatorcontrib><title>The effect of microvascular pattern alterations on network resistance in spontaneously hypertensive rats</title><title>Medical & biological engineering & computing</title><addtitle>Med Biol Eng Comput</addtitle><addtitle>Med Biol Eng Comput</addtitle><description>Structural microvascular rarefaction, defined by a loss of vessels, is a common characteristic of hypertension and has been associated with elevated microvascular resistance. However, determining the causal relationship between microvascular network structure and resistance requires a consideration of all pattern changes throughout a network. The objectives of this study were to determine whether microvascular rarefaction is associated with other network pattern alterations and to evaluate whether pattern alterations in hypertension necessarily contribute to increased microvascular resistance. Mesenteric tissues from age-matched (15–16 weeks) male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were harvested and immunolabeled for PECAM. SHR networks displayed a decreased microvascular area, arteriolar-venular (AV) length, number of AV branches, and number of capillary segments. In addition, SHR networks displayed increased AV connections per network compared to WKY networks. Based on network geometries, resistance per network was calculated using a computational model. For simulations with equal vessel diameter and with relative diameters based on reported intravital measurements, SHR microvascular network resistance was not elevated compared to the WKY level. Our results suggest that microvascular pattern alterations associated with hypertension are more complex than vessel loss, and that these combined alterations do not necessarily lead to elevated resistance.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical engineering</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Blood pressure</subject><subject>Blood vessels</subject><subject>Computer Applications</subject><subject>Human Physiology</subject><subject>Hypertension</subject><subject>Hypertension - pathology</subject><subject>Hypertension - physiopathology</subject><subject>Imaging</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Mesentery</subject><subject>Microcirculation - physiology</subject><subject>Microvessels - pathology</subject><subject>Morphology</subject><subject>Original Article</subject><subject>Radiology</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred WKY</subject><subject>Rodents</subject><subject>Splanchnic Circulation - 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pathology</topic><topic>Hypertension - physiopathology</topic><topic>Imaging</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Mesentery</topic><topic>Microcirculation - physiology</topic><topic>Microvessels - pathology</topic><topic>Morphology</topic><topic>Original Article</topic><topic>Radiology</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred WKY</topic><topic>Rodents</topic><topic>Splanchnic Circulation - physiology</topic><topic>Studies</topic><topic>Vascular Resistance - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Ming</creatorcontrib><creatorcontrib>Murfee, Walter L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Computer and Information Systems Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Physical Education Index</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Computing Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>Computer Science Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>ABI/INFORM Global</collection><collection>Computing Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>One Business (ProQuest)</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical & biological engineering & computing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Ming</au><au>Murfee, Walter L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of microvascular pattern alterations on network resistance in spontaneously hypertensive rats</atitle><jtitle>Medical & biological engineering & computing</jtitle><stitle>Med Biol Eng Comput</stitle><addtitle>Med Biol Eng Comput</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>50</volume><issue>6</issue><spage>585</spage><epage>593</epage><pages>585-593</pages><issn>0140-0118</issn><eissn>1741-0444</eissn><abstract>Structural microvascular rarefaction, defined by a loss of vessels, is a common characteristic of hypertension and has been associated with elevated microvascular resistance. However, determining the causal relationship between microvascular network structure and resistance requires a consideration of all pattern changes throughout a network. The objectives of this study were to determine whether microvascular rarefaction is associated with other network pattern alterations and to evaluate whether pattern alterations in hypertension necessarily contribute to increased microvascular resistance. Mesenteric tissues from age-matched (15–16 weeks) male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were harvested and immunolabeled for PECAM. SHR networks displayed a decreased microvascular area, arteriolar-venular (AV) length, number of AV branches, and number of capillary segments. In addition, SHR networks displayed increased AV connections per network compared to WKY networks. Based on network geometries, resistance per network was calculated using a computational model. For simulations with equal vessel diameter and with relative diameters based on reported intravital measurements, SHR microvascular network resistance was not elevated compared to the WKY level. Our results suggest that microvascular pattern alterations associated with hypertension are more complex than vessel loss, and that these combined alterations do not necessarily lead to elevated resistance.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22562369</pmid><doi>10.1007/s11517-012-0912-x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antibodies Biomedical and Life Sciences Biomedical engineering Biomedical Engineering and Bioengineering Biomedicine Blood pressure Blood vessels Computer Applications Human Physiology Hypertension Hypertension - pathology Hypertension - physiopathology Imaging Laboratories Male Medical imaging Mesentery Microcirculation - physiology Microvessels - pathology Morphology Original Article Radiology Rats Rats, Inbred SHR Rats, Inbred WKY Rodents Splanchnic Circulation - physiology Studies Vascular Resistance - physiology |
| title | The effect of microvascular pattern alterations on network resistance in spontaneously hypertensive rats |
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