GnRH Pulse Frequency-Dependent Stimulation of FSHβ Transcription Is Mediated via Activation of PKA and CREB

Expression of pituitary FSH and LH, under the control of pulsatile GnRH, is essential for fertility. cAMP response element-binding protein (CREB) has been implicated in the regulation of FSHβ gene expression, but the molecular mechanisms by which pulsatile GnRH regulates CREB activation remain poorl...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2013-04, Vol.27 (4), p.606-618
Hauptverfasser:	Thompson, Iain R, Ciccone, Nick A, Xu, Shuyun, Zaytseva, Sofiya, Carroll, Rona S, Kaiser, Ursula B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Enzyme Activation - drug effects Follicle Stimulating Hormone, beta Subunit - genetics Gene Expression Regulation - drug effects Genes, Dominant Gonadotropin-Releasing Hormone - pharmacology Mice Original Research Phosphorylation - drug effects Protein Kinase Inhibitors - pharmacology RNA, Messenger - genetics RNA, Messenger - metabolism Transcription, Genetic - drug effects
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