Decreased NKp46 and NKG2D and elevated PD‐1 are associated with altered NK‐cell function in pediatric transplant patients with PTLD

Post‐transplantation lymphoproliferative disorders (PTLD) are life‐threatening complications of organ transplantation caused by EBV infection and the use of chronic immunosuppression. While T‐cell impairment is known to play a critical role in the immunopathogenesis of EBV complications post‐transpl...

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Veröffentlicht in:	European journal of immunology 2012-02, Vol.42 (2), p.541-550
Hauptverfasser:	Wiesmayr, Silke, Webber, Steven A., Macedo, Camila, Popescu, Iulia, Smith, Louise, Luce, Jane, Metes, Diana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent CD56 Antigen - metabolism Cell Growth Processes Cells, Cultured Child Child, Preschool Cytotoxicity, Immunologic EBV Epstein-Barr virus Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - immunology Female Gene Expression Regulation - immunology Heart Transplantation Herpesvirus 4, Human - immunology Herpesvirus 4, Human - pathogenicity Humans Immunosuppression Infant Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Killer Cells, Natural - pathology Killer Cells, Natural - virology Lung Transplantation Lymphoproliferative Disorders - etiology Lymphoproliferative Disorders - immunology Male Natural Cytotoxicity Triggering Receptor 1 - genetics Natural Cytotoxicity Triggering Receptor 1 - immunology Natural Cytotoxicity Triggering Receptor 1 - metabolism NK Cell Lectin-Like Receptor Subfamily K - genetics NK Cell Lectin-Like Receptor Subfamily K - immunology NK Cell Lectin-Like Receptor Subfamily K - metabolism NK cells Pediatric Postoperative Complications Programmed Cell Death 1 Receptor - genetics Programmed Cell Death 1 Receptor - immunology Programmed Cell Death 1 Receptor - metabolism PTLD Thoracic organ transplantation
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