C-Npys ( S-3-nitro-2-pyridinesulfenyl) and peptide derivatives can inhibit a serine-thiol proteinase activity from Paracoccidioides brasiliensis

The inhibitory capacity of C-Npys ( S-[3-nitro-2-pyridinesulfenyl]) derivatives over thiol-containing serine proteases has never been tested. In the present work we used an extracellular serine-thiol proteinase activity from the fungal pathogen Paracoccidioides brasiliensis (PbST) to describe a pote...

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Veröffentlicht in:	Biochemical and biophysical research communications 2007-04, Vol.355 (4), p.1000-1005
Hauptverfasser:	Matsuo, Alisson L., Carmona, Adriana K., Silva, Luiz S., Cunha, Carlos E.L., Nakayasu, Ernesto S., Almeida, Igor C., Juliano, Maria A., Puccia, Rosana
Format:	Artikel
Sprache:	eng
Schlagworte:	Cysteine Endopeptidases - metabolism Cysteine Proteinase Inhibitors - chemistry Cysteine Proteinase Inhibitors - pharmacology Molecular Structure Npys Paracoccidioides - enzymology Paracoccidioides brasiliensis Peptides - chemistry Peptides - pharmacology Pyridines - chemistry Pyridines - pharmacology Serine Endopeptidases - metabolism Serine Proteinase Inhibitors - chemistry Serine Proteinase Inhibitors - pharmacology Serine-thiol proteinase
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