Identification and profiling of CXCR3–CXCR4 chemokine receptor heteromer complexes

Background and Purpose The C‐X‐C chemokine receptors 3 (CXCR3) and C‐X‐C chemokine receptors 4 (CXCR4) are involved in various autoimmune diseases and cancers. Small antagonists have previously been shown to cross‐inhibit chemokine binding to CXCR4, CC chemokine receptors 2 (CCR2) and 5 (CCR5) heter...

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Veröffentlicht in:	British journal of pharmacology 2013-04, Vol.168 (7), p.1662-1674
Hauptverfasser:	Watts, AO, Lipzig, MMH, Jaeger, WC, Seeber, RM, Zwam, M, Vinet, J, Lee, MMC, Siderius, M, Zaman, GJR, Boddeke, HWGM, Smit, MJ, Pfleger, KDG, Leurs, R, Vischer, HF
Format:	Artikel
Sprache:	eng
Schlagworte:	Arrestins - metabolism beta-Arrestins Cell Membrane - metabolism Chemokine CXCL10 - metabolism Chemokine CXCL12 - metabolism chemokine receptor Chemokines Competition CXCR3 CXCR4 Fluorescence Resonance Energy Transfer GPCR HEK293 Cells heteromerization HIV Human immunodeficiency virus Humans Immune system Immunoprecipitation Leukocytes Ligands Protein Binding Protein Multimerization Radioligand Assay radioligand binding Receptors, CXCR3 - agonists Receptors, CXCR3 - metabolism Receptors, CXCR4 - agonists Receptors, CXCR4 - metabolism Research Papers Signal Transduction β‐arrestin
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