Testing the Sulfotransferase Molecular Pore Hypothesis

Human cytosolic sulfotransferases (SULTs) regulate the activities of hundreds of signaling metabolites via transfer of the sulfuryl moiety (-SO3) from activated sulfate (3′-phosphoadenosine 5′-phosphosulfate) to the hydroxyls and primary amines of xeno- and endobiotics. How SULTs select substrates f...

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Veröffentlicht in:	The Journal of biological chemistry 2013-03, Vol.288 (12), p.8619-8626
Hauptverfasser:	Cook, Ian, Wang, Ting, Almo, Steven C., Kim, Jungwook, Falany, Charles N., Leyh, Thomas S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Catalytic Domain Crystallography, X-Ray Dehydroepiandrosterone - chemistry Enzyme Kinetics Enzyme Mutation Enzyme Structure Enzymology Humans Hydrophobic and Hydrophilic Interactions Kinetics Models, Molecular Mutagenesis, Site-Directed Protein Binding Raloxifene Hydrochloride - chemistry Steroid Sulfotransferase Sulfotransferases - chemistry Sulfotransferases - genetics Thermodynamics
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