Genome-wide association study identifies multiple loci influencing human serum metabolite levels

Samuli Ripatti and colleagues report a genome-wide association study for human serum metabolites using NMR of serum samples from over 8,000 Finnish individuals. They identify 31 loci associated with at least one of 216 serum metabolic measures. Nuclear magnetic resonance assays allow for measurement...

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Veröffentlicht in:	Nature genetics 2012-03, Vol.44 (3), p.269-276
Hauptverfasser:	Kettunen, Johannes, Tukiainen, Taru, Sarin, Antti-Pekka, Ortega-Alonso, Alfredo, Tikkanen, Emmi, Lyytikäinen, Leo-Pekka, Kangas, Antti J, Soininen, Pasi, Würtz, Peter, Silander, Kaisa, Dick, Danielle M, Rose, Richard J, Savolainen, Markku J, Viikari, Jorma, Kähönen, Mika, Lehtimäki, Terho, Pietiläinen, Kirsi H, Inouye, Michael, McCarthy, Mark I, Jula, Antti, Eriksson, Johan, Raitakari, Olli T, Salomaa, Veikko, Kaprio, Jaakko, Järvelin, Marjo-Riitta, Peltonen, Leena, Perola, Markus, Freimer, Nelson B, Ala-Korpela, Mika, Palotie, Aarno, Ripatti, Samuli
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/205/2138 631/443/319/320 692/699/317 Agriculture Amino Acids - metabolism Analysis of Variance Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Diabetes Disease Estimates Finland Fundamental and applied biological sciences. Psychology Gene Function Genetics Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Genomes Genotype Genotype & phenotype Hospitals Human Genetics Humans Inheritance Patterns - genetics Lipid Metabolism - genetics Lipids Magnetic Resonance Spectroscopy Metabolites Metabolome NMR Nuclear magnetic resonance Phenotype Physiological aspects Polymorphism, Single Nucleotide - genetics Quantitative Trait Loci - genetics Ratios Risk assessment Serum - metabolism Single nucleotide polymorphisms Studies
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