Matrix metalloproteinase-7 coordinates airway epithelial injury response and differentiation of ciliated cells

Matrix metalloproteinase-7 (MMP7) expression is quickly up-regulated after injury, and functions to regulate wound repair and various mucosal immune processes. We evaluated the global transcriptional response of airway epithelial cells from wild-type and Mmp7-null mice cultured at an air-liquid inte...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2013-03, Vol.48 (3), p.390-396
Hauptverfasser:	Gharib, Sina A, Altemeier, William A, Van Winkle, Laura S, Plopper, Charles G, Schlesinger, Saundra Y, Buell, Catherine A, Brauer, Rena, Lee, Vivian, Parks, William C, Chen, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - physiology Cells, Cultured Epithelial Cells - enzymology Epithelial Cells - pathology Gene Expression Genotype Lung Injury - enzymology Lung Injury - genetics Lung Injury - physiopathology Male Matrix Metalloproteinase 7 - genetics Matrix Metalloproteinase 7 - metabolism Mice Mice, Inbred C57BL Respiratory Mucosa - enzymology Respiratory Mucosa - injuries Respiratory Mucosa - innervation Respiratory Mucosa - pathology Respiratory Mucosa - physiopathology Transcription, Genetic Transcriptome Up-Regulation Wound Healing - genetics Wound Healing - physiology
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