The SLC41 family of MgtE-like magnesium transporters
Magnesium is one of the most predominant intracellular divalent cations and is requisite to the regulation of a diverse array of cellular functions. Although accumulating data from multiple studies have begun to illuminate the critical role(s) played by Mg2+ transporters in pathways involved in cell...
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| Veröffentlicht in: | Molecular aspects of medicine 2013-04, Vol.34 (2-3), p.620-628 |
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| container_title | Molecular aspects of medicine |
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| creator | Sahni, Jaya Scharenberg, Andrew M. |
| description | Magnesium is one of the most predominant intracellular divalent cations and is requisite to the regulation of a diverse array of cellular functions. Although accumulating data from multiple studies have begun to illuminate the critical role(s) played by Mg2+ transporters in pathways involved in cell signaling, metabolism, growth and proliferation, there is still a lack of understanding of the underlying molecular mechanisms that govern those various functions. In this review, we focus on the recently described SLC41 family of magnesium transporters, two members of which have been shown to mediate Mg2+ uptake and transport, and highlight what is known about their expression, localization, and function, as well as their roles and contributions to cellular Mg2+ transport. |
| doi_str_mv | 10.1016/j.mam.2012.05.012 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0098-2997 |
| ispartof | Molecular aspects of medicine, 2013-04, Vol.34 (2-3), p.620-628 |
| issn | 0098-2997 1872-9452 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amino Acid Sequence Cation Transport Proteins - genetics Cation Transport Proteins - metabolism Cation Transport Proteins - physiology Humans Magnesium Magnesium - metabolism Membrane Metabolic Networks and Pathways - genetics MgtE Models, Biological Models, Molecular Molecular Sequence Data Multigene Family - genetics Protein Conformation Sequence Alignment Signal Transduction - genetics Solute carrier 41 (SLC41) Transporter TRPM7-deficient |
| title | The SLC41 family of MgtE-like magnesium transporters |
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