Augmentation index and aortic stiffness in bicuspid aortic valve patients with non-dilated proximal aortas
We compared aortic stiffness, aortic impedance and pressure from wave reflections in the setting of bicuspid aortic valve (BAV) to the tricuspid aortic valve (TAV) in the absence of proximal aortic dilation. We hypothesized BAV is associated with abnormal arterial stiffness. Ten BAV subjects (47 ± 4...
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description | We compared aortic stiffness, aortic impedance and pressure from wave reflections in the setting of bicuspid aortic valve (BAV) to the tricuspid aortic valve (TAV) in the absence of proximal aortic dilation. We hypothesized BAV is associated with abnormal arterial stiffness.
Ten BAV subjects (47 ± 4 years, 6 male) and 13 TAV subjects (46 ± 4 years, 10 male) without significant aortic valve disease were prospectively recruited. Characteristic impedance (Zc) was derived from echocardiographic images and pulse wave Doppler of the left ventricular outflow tract. Applanation tonometry was performed to obtain pulse wave velocity (PWV) at several sites as measures of arterial stiffness and augmentation index (AIx) as a measure of wave reflection.
There were no significant differences between BAV and TAV subjects with regard to heart rate or blood pressure. Zc was similar between BAV and TAV subjects (p=0.25) as was carotid-femoral pulse wave velocity (cf-PWV) and carotid-radial PWV (cr-PWV) between BAV and TAV subjects (p=0.99). Carotid AIx was significantly higher in BAV patients compared with TAV patients (14.3 ± 4.18% versus -3.02 ± 3.96%, p=0.007).
Aortic stiffness and impedance is similar between subjects with BAV and TAV with normal aortic dimensions. The significantly higher carotid AIx in BAV, a proxy of increased pressure from wave reflections, may reflect abnormal vascular function distal to the aorta. |
doi_str_mv | 10.1186/1471-2261-13-19 |
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Ten BAV subjects (47 ± 4 years, 6 male) and 13 TAV subjects (46 ± 4 years, 10 male) without significant aortic valve disease were prospectively recruited. Characteristic impedance (Zc) was derived from echocardiographic images and pulse wave Doppler of the left ventricular outflow tract. Applanation tonometry was performed to obtain pulse wave velocity (PWV) at several sites as measures of arterial stiffness and augmentation index (AIx) as a measure of wave reflection.
There were no significant differences between BAV and TAV subjects with regard to heart rate or blood pressure. Zc was similar between BAV and TAV subjects (p=0.25) as was carotid-femoral pulse wave velocity (cf-PWV) and carotid-radial PWV (cr-PWV) between BAV and TAV subjects (p=0.99). Carotid AIx was significantly higher in BAV patients compared with TAV patients (14.3 ± 4.18% versus -3.02 ± 3.96%, p=0.007).
Aortic stiffness and impedance is similar between subjects with BAV and TAV with normal aortic dimensions. The significantly higher carotid AIx in BAV, a proxy of increased pressure from wave reflections, may reflect abnormal vascular function distal to the aorta.</description><identifier>ISSN: 1471-2261</identifier><identifier>EISSN: 1471-2261</identifier><identifier>DOI: 10.1186/1471-2261-13-19</identifier><identifier>PMID: 23496804</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Analysis ; Aorta ; Aorta - diagnostic imaging ; Aorta - physiopathology ; Aortic valve ; Aortic Valve - abnormalities ; Aortic Valve - diagnostic imaging ; Aortic Valve - physiopathology ; Arterial Pressure ; Bicuspid Aortic Valve Disease ; Chi-Square Distribution ; Comparative analysis ; Consent ; Coronary vessels ; Echocardiography, Doppler, Pulsed ; Female ; Flow velocity ; Heart beat ; Heart Rate ; Heart valve diseases ; Heart Valve Diseases - diagnostic imaging ; Heart Valve Diseases - physiopathology ; Humans ; Hypotheses ; Male ; Manometry ; Middle Aged ; Physiological aspects ; Predictive Value of Tests ; Prospective Studies ; Pulse Wave Analysis ; Studies ; Vascular Stiffness ; Veins & arteries</subject><ispartof>BMC cardiovascular disorders, 2013-03, Vol.13 (1), p.19-19, Article 19</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Warner et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright ©2013 Warner et al.; licensee BioMed Central Ltd. 2013 Warner et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-50e43bab3415822c26ab39c5a0be0ec0b89d955ec0a30788f428aa5d5b4486933</citedby><cites>FETCH-LOGICAL-c488t-50e43bab3415822c26ab39c5a0be0ec0b89d955ec0a30788f428aa5d5b4486933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602003/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602003/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23496804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Warner, Patrick J</creatorcontrib><creatorcontrib>Al-Quthami, Adeeb</creatorcontrib><creatorcontrib>Brooks, Erica L</creatorcontrib><creatorcontrib>Kelley-Hedgepeth, Alyson</creatorcontrib><creatorcontrib>Patvardhan, Eshan</creatorcontrib><creatorcontrib>Kuvin, Jeffrey T</creatorcontrib><creatorcontrib>Heffernan, Kevin S</creatorcontrib><creatorcontrib>Huggins, Gordon S</creatorcontrib><title>Augmentation index and aortic stiffness in bicuspid aortic valve patients with non-dilated proximal aortas</title><title>BMC cardiovascular disorders</title><addtitle>BMC Cardiovasc Disord</addtitle><description>We compared aortic stiffness, aortic impedance and pressure from wave reflections in the setting of bicuspid aortic valve (BAV) to the tricuspid aortic valve (TAV) in the absence of proximal aortic dilation. We hypothesized BAV is associated with abnormal arterial stiffness.
Ten BAV subjects (47 ± 4 years, 6 male) and 13 TAV subjects (46 ± 4 years, 10 male) without significant aortic valve disease were prospectively recruited. Characteristic impedance (Zc) was derived from echocardiographic images and pulse wave Doppler of the left ventricular outflow tract. Applanation tonometry was performed to obtain pulse wave velocity (PWV) at several sites as measures of arterial stiffness and augmentation index (AIx) as a measure of wave reflection.
There were no significant differences between BAV and TAV subjects with regard to heart rate or blood pressure. Zc was similar between BAV and TAV subjects (p=0.25) as was carotid-femoral pulse wave velocity (cf-PWV) and carotid-radial PWV (cr-PWV) between BAV and TAV subjects (p=0.99). Carotid AIx was significantly higher in BAV patients compared with TAV patients (14.3 ± 4.18% versus -3.02 ± 3.96%, p=0.007).
Aortic stiffness and impedance is similar between subjects with BAV and TAV with normal aortic dimensions. The significantly higher carotid AIx in BAV, a proxy of increased pressure from wave reflections, may reflect abnormal vascular function distal to the aorta.</description><subject>Adult</subject><subject>Analysis</subject><subject>Aorta</subject><subject>Aorta - diagnostic imaging</subject><subject>Aorta - physiopathology</subject><subject>Aortic valve</subject><subject>Aortic Valve - abnormalities</subject><subject>Aortic Valve - diagnostic imaging</subject><subject>Aortic Valve - physiopathology</subject><subject>Arterial Pressure</subject><subject>Bicuspid Aortic Valve Disease</subject><subject>Chi-Square Distribution</subject><subject>Comparative analysis</subject><subject>Consent</subject><subject>Coronary vessels</subject><subject>Echocardiography, Doppler, Pulsed</subject><subject>Female</subject><subject>Flow velocity</subject><subject>Heart beat</subject><subject>Heart Rate</subject><subject>Heart valve diseases</subject><subject>Heart Valve Diseases - diagnostic imaging</subject><subject>Heart Valve Diseases - physiopathology</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Male</subject><subject>Manometry</subject><subject>Middle Aged</subject><subject>Physiological aspects</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Pulse Wave Analysis</subject><subject>Studies</subject><subject>Vascular Stiffness</subject><subject>Veins & arteries</subject><issn>1471-2261</issn><issn>1471-2261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkstv1DAQxi1ERUvhzA1Z4sIlrZ-JfUFaVeUhVeICZ8txJluvEjvYyVL--zp9LC1CPng085vPM9aH0DtKzihV9TkVDa0Yq2lFeUX1C3RyyLx8Eh-j1znvCKGNIvoVOmZc6FoRcYJ2m2U7Qpjt7GPAPnRwg23osI1p9g7n2fd9gJxLCbfeLXnyh-LeDnvAU2ktAhn_9vM1DjFUnR_sDB2eUrzxox3ueJvfoKPeDhnePtyn6Ofnyx8XX6ur71--XWyuKieUmitJQPDWtlxQqRhzrC6xdtKSFgg40irdaSlLZDlplOoFU9bKTrZCqFpzfoo-3etOSztC58pwyQ5mSmWW9MdE683zSvDXZhv3hteEEbIKfHwQSPHXAnk2o88OhsEGiEs2lJev10TdoR_-QXdxSaGst1KNJFJT9pfa2gGMD30s77pV1GwkF1I1NaOFOvsPVU4Ho3cxQO9L_lnD-X2DSzHnBP1hR0rMag-zGsCsBijTGKpLx_unX3PgH_3AbwFpxLVU</recordid><startdate>20130315</startdate><enddate>20130315</enddate><creator>Warner, Patrick J</creator><creator>Al-Quthami, Adeeb</creator><creator>Brooks, Erica L</creator><creator>Kelley-Hedgepeth, Alyson</creator><creator>Patvardhan, Eshan</creator><creator>Kuvin, Jeffrey T</creator><creator>Heffernan, Kevin S</creator><creator>Huggins, Gordon S</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130315</creationdate><title>Augmentation index and aortic stiffness in bicuspid aortic valve patients with non-dilated proximal aortas</title><author>Warner, Patrick J ; Al-Quthami, Adeeb ; Brooks, Erica L ; Kelley-Hedgepeth, Alyson ; Patvardhan, Eshan ; Kuvin, Jeffrey T ; Heffernan, Kevin S ; Huggins, Gordon S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-50e43bab3415822c26ab39c5a0be0ec0b89d955ec0a30788f428aa5d5b4486933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Aorta</topic><topic>Aorta - diagnostic imaging</topic><topic>Aorta - physiopathology</topic><topic>Aortic valve</topic><topic>Aortic Valve - abnormalities</topic><topic>Aortic Valve - diagnostic imaging</topic><topic>Aortic Valve - physiopathology</topic><topic>Arterial Pressure</topic><topic>Bicuspid Aortic Valve Disease</topic><topic>Chi-Square Distribution</topic><topic>Comparative analysis</topic><topic>Consent</topic><topic>Coronary vessels</topic><topic>Echocardiography, Doppler, Pulsed</topic><topic>Female</topic><topic>Flow velocity</topic><topic>Heart beat</topic><topic>Heart Rate</topic><topic>Heart valve diseases</topic><topic>Heart Valve Diseases - diagnostic imaging</topic><topic>Heart Valve Diseases - physiopathology</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Male</topic><topic>Manometry</topic><topic>Middle Aged</topic><topic>Physiological aspects</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Pulse Wave Analysis</topic><topic>Studies</topic><topic>Vascular Stiffness</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Warner, Patrick J</creatorcontrib><creatorcontrib>Al-Quthami, Adeeb</creatorcontrib><creatorcontrib>Brooks, Erica L</creatorcontrib><creatorcontrib>Kelley-Hedgepeth, Alyson</creatorcontrib><creatorcontrib>Patvardhan, Eshan</creatorcontrib><creatorcontrib>Kuvin, Jeffrey T</creatorcontrib><creatorcontrib>Heffernan, Kevin S</creatorcontrib><creatorcontrib>Huggins, Gordon S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC cardiovascular disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Warner, Patrick J</au><au>Al-Quthami, Adeeb</au><au>Brooks, Erica L</au><au>Kelley-Hedgepeth, Alyson</au><au>Patvardhan, Eshan</au><au>Kuvin, Jeffrey T</au><au>Heffernan, Kevin S</au><au>Huggins, Gordon S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Augmentation index and aortic stiffness in bicuspid aortic valve patients with non-dilated proximal aortas</atitle><jtitle>BMC cardiovascular disorders</jtitle><addtitle>BMC Cardiovasc Disord</addtitle><date>2013-03-15</date><risdate>2013</risdate><volume>13</volume><issue>1</issue><spage>19</spage><epage>19</epage><pages>19-19</pages><artnum>19</artnum><issn>1471-2261</issn><eissn>1471-2261</eissn><abstract>We compared aortic stiffness, aortic impedance and pressure from wave reflections in the setting of bicuspid aortic valve (BAV) to the tricuspid aortic valve (TAV) in the absence of proximal aortic dilation. We hypothesized BAV is associated with abnormal arterial stiffness.
Ten BAV subjects (47 ± 4 years, 6 male) and 13 TAV subjects (46 ± 4 years, 10 male) without significant aortic valve disease were prospectively recruited. Characteristic impedance (Zc) was derived from echocardiographic images and pulse wave Doppler of the left ventricular outflow tract. Applanation tonometry was performed to obtain pulse wave velocity (PWV) at several sites as measures of arterial stiffness and augmentation index (AIx) as a measure of wave reflection.
There were no significant differences between BAV and TAV subjects with regard to heart rate or blood pressure. Zc was similar between BAV and TAV subjects (p=0.25) as was carotid-femoral pulse wave velocity (cf-PWV) and carotid-radial PWV (cr-PWV) between BAV and TAV subjects (p=0.99). Carotid AIx was significantly higher in BAV patients compared with TAV patients (14.3 ± 4.18% versus -3.02 ± 3.96%, p=0.007).
Aortic stiffness and impedance is similar between subjects with BAV and TAV with normal aortic dimensions. The significantly higher carotid AIx in BAV, a proxy of increased pressure from wave reflections, may reflect abnormal vascular function distal to the aorta.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>23496804</pmid><doi>10.1186/1471-2261-13-19</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Analysis Aorta Aorta - diagnostic imaging Aorta - physiopathology Aortic valve Aortic Valve - abnormalities Aortic Valve - diagnostic imaging Aortic Valve - physiopathology Arterial Pressure Bicuspid Aortic Valve Disease Chi-Square Distribution Comparative analysis Consent Coronary vessels Echocardiography, Doppler, Pulsed Female Flow velocity Heart beat Heart Rate Heart valve diseases Heart Valve Diseases - diagnostic imaging Heart Valve Diseases - physiopathology Humans Hypotheses Male Manometry Middle Aged Physiological aspects Predictive Value of Tests Prospective Studies Pulse Wave Analysis Studies Vascular Stiffness Veins & arteries |
title | Augmentation index and aortic stiffness in bicuspid aortic valve patients with non-dilated proximal aortas |
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