Aquaporin-4： orthogonal array assembly, CNS functions, and role in neuromyelitis optica

Aquaporin-4 （AQP4） is a water-selective transporter expressed in astrocytes throughout the central nervous system, as well as in kidney, lung, stomach and skeletal muscle. The two AQP4 isoforms produced by alternative spicing, M1 and M23 AQP4, form heterotetramers that assemble in cell plasma membra...

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Veröffentlicht in:	Acta pharmacologica Sinica 2011-06, Vol.32 (6), p.702-710
Hauptverfasser:	Verkman, Alan S, Ratelade, Julien, Rossi, Andrea, Zhang, Hua, Tradtrantip, Lukmanee
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - therapeutic use Aquaporin 4 - chemistry Aquaporin 4 - immunology Aquaporin 4 - physiology Biomedical and Life Sciences Biomedicine Central Nervous System - immunology Central Nervous System - metabolism Central Nervous System - physiology Drug Discovery High-Throughput Screening Assays Humans Immunology Internal Medicine Medical Microbiology Molecular Sequence Data Neuromyelitis Optica - drug therapy Neuromyelitis Optica - immunology Neuromyelitis Optica - metabolism Pharmacology/Toxicology Protein Binding Protein Multimerization Review Small Molecule Libraries - chemistry Small Molecule Libraries - therapeutic use Vaccine 中枢神经系统星形胶质细胞正交表水通道蛋白4 神经胶质胶质纤维酸性蛋白自身免疫性视神经
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