Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants

We conducted a systematic study of top susceptibility variants from a genome-wide association (GWA) study of bipolar disorder to gain insight into the functional consequences of genetic variation influencing disease risk. We report here the results of experiments to explore the effects of these susc...

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Veröffentlicht in:	Molecular psychiatry 2013-03, Vol.18 (3), p.340-346
Hauptverfasser:	Gamazon, E R, Badner, J A, Cheng, L, Zhang, C, Zhang, D, Cox, N J, Gershon, E S, Kelsoe, J R, Greenwood, T A, Nievergelt, C M, Chen, C, McKinney, R, Shilling, P D, Schork, N J, Smith, E N, Bloss, C S, Nurnberger, J I, Edenberg, H J, Foroud, T, Koller, D L, Scheftner, W A, Coryell, W, Rice, J, Lawson, W B, Nwulia, E A, Hipolito, M, Byerley, W, McMahon, F J, Schulze, T G, Berrettini, W H, Potash, J B, Zandi, P P, Mahon, P B, McInnis, M G, Zöllner, S, Zhang, P, Craig, D W, Szelinger, S, Barrett, T B, Liu, C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/200 631/208/727/2000 631/208/729/743 692/699/476/1333 Adult and adolescent clinical studies Behavioral Sciences Biological and medical sciences Biological Psychology Bipolar disorder Bipolar Disorder - genetics Bipolar disorders Cerebellum Cerebellum - metabolism CpG islands DNA methylation DNA Methylation - genetics Epigenetics Gene expression Gene Expression Regulation - genetics Gene loci Genetic aspects Genetic diversity Genetic Predisposition to Disease - genetics Genetic susceptibility Genome-Wide Association Study Genomes Humans Identification and classification Lymphocytes Medical sciences Medicine Medicine & Public Health Methylation Mood disorders Neurosciences original-article Pharmacotherapy Polymorphism, Single Nucleotide - genetics Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Quantitative trait loci Quantitative Trait Loci - genetics Risk factors Single nucleotide polymorphisms Single-nucleotide polymorphism Susceptibility
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