Pharmacometric Approaches to Guide Dose Selection of the Novel GPR40 Agonist TAK‐875 in Subjects With Type 2 Diabetes Mellitus

The G‐protein‐coupled receptor 40 agonist (GPR40) TAK‐875 is being developed as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus. Pharmacometric approaches such as model‐based exposure‐response and meta‐analyses were applied to (i) characterize ex...

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Veröffentlicht in:	CPT: pharmacometrics and systems pharmacology 2013-01, Vol.2 (1), p.1-10
Hauptverfasser:	Naik, H, Lu, J, Cao, C, Pfister, M, Vakilynejad, M, Leifke, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Clinical trials Demographics Diabetes Drug dosages Estimates Glucose Hemoglobin Hypoglycemia Insulin Original Population R&D Research & development Simulation Studies
Online-Zugang:	Volltext
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