Dose-dependent effects of vitamin D on transdifferentiation of skeletal muscle cells to adipose cells

Fat infiltration within muscle is one of a number of features of vitamin D deficiency, which leads to a decline in muscle functionality. The origin of this fat is unclear, but one possibility is that it forms from myogenic precursor cells present in the muscle, which transdifferentiate into mature a...

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Veröffentlicht in:	Journal of endocrinology 2013-04, Vol.217 (1), p.45-58
Hauptverfasser:	Ryan, Kevin J P, Daniel, Zoe C T R, Craggs, Lucinda J L, Parr, Tim, Brameld, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes, Brown - cytology Adipocytes, Brown - metabolism Adipocytes, White - cytology Adipocytes, White - metabolism Adipogenesis Animals Biomarkers - metabolism Calcitriol - adverse effects Calcitriol - metabolism Cell Line Cell Transdifferentiation Fatty Acid-Binding Proteins - genetics Fatty Acid-Binding Proteins - metabolism Gene Expression Regulation Lipogenesis Mice Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - metabolism Muscle, Skeletal - cytology Muscle, Skeletal - metabolism Osmolar Concentration PPAR gamma - genetics PPAR gamma - metabolism Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Up-Regulation
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