A Case-Control Study between Gene Polymorphisms of Polyunsaturated Fatty Acid Metabolic Rate-Limiting Enzymes and Acute Coronary Syndrome in Chinese Han Population
The purpose of this study is to analyze the relationship between the polymorphisms of fatty acid desaturase 1 (FADS1), fatty acid desaturase 2 (FADS2), and elongation of very long-chain fatty acids-like 2 (ELOVL2) and acute coronary syndrome (ACS) in Chinese Han population. Therefore, we selected th...
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| creator | Jiang, Yanfang Qin, Ling Cao, Hong-Yan Song, Zikai |
| description | The purpose of this study is to analyze the relationship between the polymorphisms of fatty acid desaturase 1 (FADS1), fatty acid desaturase 2 (FADS2), and elongation of very long-chain fatty acids-like 2 (ELOVL2) and acute coronary syndrome (ACS) in Chinese Han population. Therefore, we selected three single nucleotide polymorphisms (SNPs) from these candidate genes and genotyped them using PCR-based restriction fragment length polymorphism analysis in 249 ACS patients and 240 non-ACS subjects, as were Han Chinese ancestry. The results showed that rs174556 in the FADS1 gene is found to be in allelic association (P=0.003) and genotypic association (P=0.036) with ACS. The frequencies of rs174556 minor allele (T) in case group were obviously higher than in control group. The trans-phase gene-gene interaction analysis showed that the combined genotype of rs174556 (T/T) and rs3756963 (T/T) was associated with ACS (P=0.031). And the results suggest that, for rs174556 C>T, the CT/TT genotypes were more likely to lead in ACS in subjects with hypertension after correction of all risk factors (OR=4.236, 95% CI, 2.216–7.126). These findings suggest that the polymorphisms of rs174556 in the FADS1 gene are very likely to be associated with ACS in Chinese Han population, especially in subjects with hypertension. |
| doi_str_mv | 10.1155/2013/928178 |
| format | Article |
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Therefore, we selected three single nucleotide polymorphisms (SNPs) from these candidate genes and genotyped them using PCR-based restriction fragment length polymorphism analysis in 249 ACS patients and 240 non-ACS subjects, as were Han Chinese ancestry. The results showed that rs174556 in the FADS1 gene is found to be in allelic association (P=0.003) and genotypic association (P=0.036) with ACS. The frequencies of rs174556 minor allele (T) in case group were obviously higher than in control group. The trans-phase gene-gene interaction analysis showed that the combined genotype of rs174556 (T/T) and rs3756963 (T/T) was associated with ACS (P=0.031). And the results suggest that, for rs174556 C>T, the CT/TT genotypes were more likely to lead in ACS in subjects with hypertension after correction of all risk factors (OR=4.236, 95% CI, 2.216–7.126). These findings suggest that the polymorphisms of rs174556 in the FADS1 gene are very likely to be associated with ACS in Chinese Han population, especially in subjects with hypertension.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2013/928178</identifier><identifier>PMID: 23555103</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acetyltransferases - genetics ; Acute Coronary Syndrome - complications ; Acute Coronary Syndrome - enzymology ; Acute Coronary Syndrome - genetics ; Acute coronary syndromes ; Adult ; Aged ; Angina pectoris ; Cardiovascular disease ; Case-Control Studies ; China ; Elongation ; Fatty Acid Desaturases - genetics ; Fatty acids ; Fatty Acids, Unsaturated - genetics ; Fatty Acids, Unsaturated - metabolism ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Heart attacks ; Humans ; Hypertension - complications ; Hypertension - enzymology ; Hypertension - genetics ; Male ; Middle Aged ; Polymorphism, Single Nucleotide</subject><ispartof>BioMed research international, 2013-01, Vol.2013 (2013), p.1-7</ispartof><rights>Copyright © 2013 Zikai Song et al.</rights><rights>Copyright © 2013 Zikai Song et al. Zikai Song et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Zikai Song et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-52d3598b36e6913c2e126b681f6616994cec200e79ce4c6a831e8762340a12453</citedby><cites>FETCH-LOGICAL-c500t-52d3598b36e6913c2e126b681f6616994cec200e79ce4c6a831e8762340a12453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600233/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600233/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23555103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ndisang, Joseph Fomusi</contributor><creatorcontrib>Jiang, Yanfang</creatorcontrib><creatorcontrib>Qin, Ling</creatorcontrib><creatorcontrib>Cao, Hong-Yan</creatorcontrib><creatorcontrib>Song, Zikai</creatorcontrib><title>A Case-Control Study between Gene Polymorphisms of Polyunsaturated Fatty Acid Metabolic Rate-Limiting Enzymes and Acute Coronary Syndrome in Chinese Han Population</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>The purpose of this study is to analyze the relationship between the polymorphisms of fatty acid desaturase 1 (FADS1), fatty acid desaturase 2 (FADS2), and elongation of very long-chain fatty acids-like 2 (ELOVL2) and acute coronary syndrome (ACS) in Chinese Han population. Therefore, we selected three single nucleotide polymorphisms (SNPs) from these candidate genes and genotyped them using PCR-based restriction fragment length polymorphism analysis in 249 ACS patients and 240 non-ACS subjects, as were Han Chinese ancestry. The results showed that rs174556 in the FADS1 gene is found to be in allelic association (P=0.003) and genotypic association (P=0.036) with ACS. The frequencies of rs174556 minor allele (T) in case group were obviously higher than in control group. The trans-phase gene-gene interaction analysis showed that the combined genotype of rs174556 (T/T) and rs3756963 (T/T) was associated with ACS (P=0.031). And the results suggest that, for rs174556 C>T, the CT/TT genotypes were more likely to lead in ACS in subjects with hypertension after correction of all risk factors (OR=4.236, 95% CI, 2.216–7.126). These findings suggest that the polymorphisms of rs174556 in the FADS1 gene are very likely to be associated with ACS in Chinese Han population, especially in subjects with hypertension.</description><subject>Acetyltransferases - genetics</subject><subject>Acute Coronary Syndrome - complications</subject><subject>Acute Coronary Syndrome - enzymology</subject><subject>Acute Coronary Syndrome - genetics</subject><subject>Acute coronary syndromes</subject><subject>Adult</subject><subject>Aged</subject><subject>Angina pectoris</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>China</subject><subject>Elongation</subject><subject>Fatty Acid Desaturases - genetics</subject><subject>Fatty acids</subject><subject>Fatty Acids, Unsaturated - genetics</subject><subject>Fatty Acids, Unsaturated - metabolism</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Hypertension - enzymology</subject><subject>Hypertension - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkk1v1DAQhiMEolXpiTuyxAUVhXo8iTe5IK2ifiAtAlE4R44z23WV2IvtUIW_wx_FZcuqcKovY3kevTOeebPsJfB3AGV5KjjgaS0qWFRPskOBUOQSCni6vyMeZMch3PB0KpC8ls-zA4FlWQLHw-zXkjUqUN44G70b2FWc-pl1FG-JLLsgS-yzG-bR-e3GhDEwt_7zMNmg4uRVpJ6dqxhnttSmZx8pqs4NRrMvKZWvzGiisdfszP6cRwpM2T6BUyTWOO-s8jO7mm3v3UjMWNZsjKVA7FLZVGU7DSoaZ19kz9ZqCHR8H4-yb-dnX5vLfPXp4kOzXOW65DzmpeixrKsOJckaUAsCITtZwVpKkHVdaNKCc1rUmgotVYVA1UIKLLgCUZR4lL3f6W6nbqReUxqJGtqtN2NqtHXKtP9mrNm01-5Hi5JzgZgE3twLePd9ohDb0QRNw6AsuSm0UGAthKzEI1AUBVaFrHhCX_-H3rjJ2zSJJCg4LhYC6kS93VHauxA8rfd9A2_vrNLeWaXdWSXRrx5-dc_-NUYCTnZA2kivbs3j1CghtFYPYATgEn8DpLTQDg</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Jiang, Yanfang</creator><creator>Qin, Ling</creator><creator>Cao, Hong-Yan</creator><creator>Song, Zikai</creator><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>A Case-Control Study between Gene Polymorphisms of Polyunsaturated Fatty Acid Metabolic Rate-Limiting Enzymes and Acute Coronary Syndrome in Chinese Han Population</title><author>Jiang, Yanfang ; Qin, Ling ; Cao, Hong-Yan ; Song, Zikai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-52d3598b36e6913c2e126b681f6616994cec200e79ce4c6a831e8762340a12453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acetyltransferases - 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Academic</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Yanfang</au><au>Qin, Ling</au><au>Cao, Hong-Yan</au><au>Song, Zikai</au><au>Ndisang, Joseph Fomusi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Case-Control Study between Gene Polymorphisms of Polyunsaturated Fatty Acid Metabolic Rate-Limiting Enzymes and Acute Coronary Syndrome in Chinese Han Population</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>2013</volume><issue>2013</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>The purpose of this study is to analyze the relationship between the polymorphisms of fatty acid desaturase 1 (FADS1), fatty acid desaturase 2 (FADS2), and elongation of very long-chain fatty acids-like 2 (ELOVL2) and acute coronary syndrome (ACS) in Chinese Han population. Therefore, we selected three single nucleotide polymorphisms (SNPs) from these candidate genes and genotyped them using PCR-based restriction fragment length polymorphism analysis in 249 ACS patients and 240 non-ACS subjects, as were Han Chinese ancestry. The results showed that rs174556 in the FADS1 gene is found to be in allelic association (P=0.003) and genotypic association (P=0.036) with ACS. The frequencies of rs174556 minor allele (T) in case group were obviously higher than in control group. The trans-phase gene-gene interaction analysis showed that the combined genotype of rs174556 (T/T) and rs3756963 (T/T) was associated with ACS (P=0.031). And the results suggest that, for rs174556 C>T, the CT/TT genotypes were more likely to lead in ACS in subjects with hypertension after correction of all risk factors (OR=4.236, 95% CI, 2.216–7.126). These findings suggest that the polymorphisms of rs174556 in the FADS1 gene are very likely to be associated with ACS in Chinese Han population, especially in subjects with hypertension.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>23555103</pmid><doi>10.1155/2013/928178</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetyltransferases - genetics Acute Coronary Syndrome - complications Acute Coronary Syndrome - enzymology Acute Coronary Syndrome - genetics Acute coronary syndromes Adult Aged Angina pectoris Cardiovascular disease Case-Control Studies China Elongation Fatty Acid Desaturases - genetics Fatty acids Fatty Acids, Unsaturated - genetics Fatty Acids, Unsaturated - metabolism Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Heart attacks Humans Hypertension - complications Hypertension - enzymology Hypertension - genetics Male Middle Aged Polymorphism, Single Nucleotide |
| title | A Case-Control Study between Gene Polymorphisms of Polyunsaturated Fatty Acid Metabolic Rate-Limiting Enzymes and Acute Coronary Syndrome in Chinese Han Population |
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