Quercetin Preserves β-Cell Mass and Function in Fructose-Induced Hyperinsulinemia through Modulating Pancreatic Akt/FoxO1 Activation

Fructose-induced hyperinsulinemia is associated with insulin compensative secretion and predicts the onset of type 2 diabetes. In this study, we investigated the preservation of dietary flavonoid quercetin on pancreatic β-cell mass and function in fructose-treated rats and INS-1 β-cells. Quercetin w...

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Veröffentlicht in:	Evidence-based complementary and alternative medicine 2013-01, Vol.2013 (2013), p.1-12
Hauptverfasser:	Wang, Wei, Wang, Ming-Xing, Li, Jian-Mei, Kong, Ling-Dong, Hu, Qing-Hua, Zhang, Xian, Fan, Chen-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation AKT protein Cell growth Cell proliferation Diabetes mellitus Diabetes mellitus (non-insulin dependent) Forkhead protein FOXO1 protein Fructose Glucose Homeobox Hyperinsulinemia Hyperplasia Insulin Islets of Langerhans Janus kinase Janus kinase 2 Kinases Leptin Nutrition research Pancreas Phosphorylation Preservation Quercetin Rats Rodents Secretion SOCS-3 protein Stat3 protein Transcription factors Transducers
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