Photoprotective and antioxidant effects of Rhubarb: inhibitory action on tyrosinase and tyrosine kinase activities and TNF-α, IL-1α and α-MSH production in human melanocytes

Exposure to ultraviolet (UV) radiation causes various forms of acute and chronic skin damage, including immunosuppression, inflammation, premature aging and photodamage. Furthermore, it induces the generation of reactive oxygen species, produces proinflammatory cytokines and melanocyte-stimulating h...

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Veröffentlicht in:	BMC complementary and alternative medicine 2013-02, Vol.13 (1), p.49-49, Article 49
Hauptverfasser:	Silveira, Jéssica P S, Seito, Leonardo N, Eberlin, Samara, Dieamant, Gustavo C, Nogueira, Cecília, Pereda, Maria C V, Di Stasi, Luiz C
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-MSH - biosynthesis Antioxidants - pharmacology Antioxidants - therapeutic use Biphenyl Compounds - metabolism Cytokines - biosynthesis Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Free Radical Scavengers - pharmacology Humans Inflammation Mediators - metabolism Interleukin-1alpha - biosynthesis Lipid Peroxidation - drug effects Melanocytes - drug effects Melanocytes - metabolism Melanocytes - radiation effects Monophenol Monooxygenase - antagonists & inhibitors Phytotherapy Picrates - metabolism Plant Extracts - pharmacology Plant Extracts - therapeutic use Protein-Tyrosine Kinases - antagonists & inhibitors Rheum Rhizome Skin - drug effects Skin - metabolism Skin - radiation effects Skin Diseases - etiology Skin Diseases - metabolism Skin Diseases - prevention & control Tumor Necrosis Factor-alpha - biosynthesis Ultraviolet Rays
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