Photoprotective and antioxidant effects of Rhubarb: inhibitory action on tyrosinase and tyrosine kinase activities and TNF-α, IL-1α and α-MSH production in human melanocytes
Exposure to ultraviolet (UV) radiation causes various forms of acute and chronic skin damage, including immunosuppression, inflammation, premature aging and photodamage. Furthermore, it induces the generation of reactive oxygen species, produces proinflammatory cytokines and melanocyte-stimulating h...
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| Veröffentlicht in: | BMC complementary and alternative medicine 2013-02, Vol.13 (1), p.49-49, Article 49 |
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| creator | Silveira, Jéssica P S Seito, Leonardo N Eberlin, Samara Dieamant, Gustavo C Nogueira, Cecília Pereda, Maria C V Di Stasi, Luiz C |
| description | Exposure to ultraviolet (UV) radiation causes various forms of acute and chronic skin damage, including immunosuppression, inflammation, premature aging and photodamage. Furthermore, it induces the generation of reactive oxygen species, produces proinflammatory cytokines and melanocyte-stimulating hormone (MSH) and increases tyrosinase activity. The aim of this study was to evaluate the potential photoprotective effects of Rheum rhaponticum L. rhizome extract on human UV-stimulated melanocytes.
The effects of Rheum rhaponticum rhizome extract on tyrosine kinase activity, and on interleukin-1α (IL-1α), tumour necrosis factor α (TNF-α), and α-MSH production in human epidermal melanocytes were evaluated under UV-stimulated and non-stimulated conditions. Antioxidant activity was evaluated by lipid peroxidation and 1,1-dyphenyl-2-picryl-hydrazyl (DPPH) assays, while anti-tyrosinase activity was evaluated by the mushroom tyrosinase method.
Rheum rhaponticum L. rhizome extract showed in vitro antioxidant properties against lipid peroxidation, free radical scavenging and anti-tyrosinase activities, and inhibited the production of IL-1α, TNF-α, α-MSH, and tyrosine kinase activity in melanocytes subjected to UV radiation.
These results support the inclusion of Rheum rhaponticum L. rhizome extract into cosmetic, sunscreen and skin care products for the prevention or reduction of photodamage. |
| doi_str_mv | 10.1186/1472-6882-13-49 |
| format | Article |
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The effects of Rheum rhaponticum rhizome extract on tyrosine kinase activity, and on interleukin-1α (IL-1α), tumour necrosis factor α (TNF-α), and α-MSH production in human epidermal melanocytes were evaluated under UV-stimulated and non-stimulated conditions. Antioxidant activity was evaluated by lipid peroxidation and 1,1-dyphenyl-2-picryl-hydrazyl (DPPH) assays, while anti-tyrosinase activity was evaluated by the mushroom tyrosinase method.
Rheum rhaponticum L. rhizome extract showed in vitro antioxidant properties against lipid peroxidation, free radical scavenging and anti-tyrosinase activities, and inhibited the production of IL-1α, TNF-α, α-MSH, and tyrosine kinase activity in melanocytes subjected to UV radiation.
These results support the inclusion of Rheum rhaponticum L. rhizome extract into cosmetic, sunscreen and skin care products for the prevention or reduction of photodamage.</description><identifier>ISSN: 1472-6882</identifier><identifier>EISSN: 1472-6882</identifier><identifier>DOI: 10.1186/1472-6882-13-49</identifier><identifier>PMID: 23445687</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>alpha-MSH - biosynthesis ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Biphenyl Compounds - metabolism ; Cytokines - biosynthesis ; Enzyme Inhibitors - pharmacology ; Enzyme Inhibitors - therapeutic use ; Free Radical Scavengers - pharmacology ; Humans ; Inflammation Mediators - metabolism ; Interleukin-1alpha - biosynthesis ; Lipid Peroxidation - drug effects ; Melanocytes - drug effects ; Melanocytes - metabolism ; Melanocytes - radiation effects ; Monophenol Monooxygenase - antagonists & inhibitors ; Phytotherapy ; Picrates - metabolism ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Protein-Tyrosine Kinases - antagonists & inhibitors ; Rheum ; Rhizome ; Skin - drug effects ; Skin - metabolism ; Skin - radiation effects ; Skin Diseases - etiology ; Skin Diseases - metabolism ; Skin Diseases - prevention & control ; Tumor Necrosis Factor-alpha - biosynthesis ; Ultraviolet Rays</subject><ispartof>BMC complementary and alternative medicine, 2013-02, Vol.13 (1), p.49-49, Article 49</ispartof><rights>Copyright ©2013 Silveira et al; licensee BioMed Central Ltd. 2013 Silveira et al; licensee BioMed Central Ltd.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b452t-4e2edacb9340e50bb8617924f245b9f176e7026b64f44772b913a6b253c481483</citedby><cites>FETCH-LOGICAL-b452t-4e2edacb9340e50bb8617924f245b9f176e7026b64f44772b913a6b253c481483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598645/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598645/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23445687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silveira, Jéssica P S</creatorcontrib><creatorcontrib>Seito, Leonardo N</creatorcontrib><creatorcontrib>Eberlin, Samara</creatorcontrib><creatorcontrib>Dieamant, Gustavo C</creatorcontrib><creatorcontrib>Nogueira, Cecília</creatorcontrib><creatorcontrib>Pereda, Maria C V</creatorcontrib><creatorcontrib>Di Stasi, Luiz C</creatorcontrib><title>Photoprotective and antioxidant effects of Rhubarb: inhibitory action on tyrosinase and tyrosine kinase activities and TNF-α, IL-1α and α-MSH production in human melanocytes</title><title>BMC complementary and alternative medicine</title><addtitle>BMC Complement Altern Med</addtitle><description>Exposure to ultraviolet (UV) radiation causes various forms of acute and chronic skin damage, including immunosuppression, inflammation, premature aging and photodamage. Furthermore, it induces the generation of reactive oxygen species, produces proinflammatory cytokines and melanocyte-stimulating hormone (MSH) and increases tyrosinase activity. The aim of this study was to evaluate the potential photoprotective effects of Rheum rhaponticum L. rhizome extract on human UV-stimulated melanocytes.
The effects of Rheum rhaponticum rhizome extract on tyrosine kinase activity, and on interleukin-1α (IL-1α), tumour necrosis factor α (TNF-α), and α-MSH production in human epidermal melanocytes were evaluated under UV-stimulated and non-stimulated conditions. Antioxidant activity was evaluated by lipid peroxidation and 1,1-dyphenyl-2-picryl-hydrazyl (DPPH) assays, while anti-tyrosinase activity was evaluated by the mushroom tyrosinase method.
Rheum rhaponticum L. rhizome extract showed in vitro antioxidant properties against lipid peroxidation, free radical scavenging and anti-tyrosinase activities, and inhibited the production of IL-1α, TNF-α, α-MSH, and tyrosine kinase activity in melanocytes subjected to UV radiation.
These results support the inclusion of Rheum rhaponticum L. rhizome extract into cosmetic, sunscreen and skin care products for the prevention or reduction of photodamage.</description><subject>alpha-MSH - biosynthesis</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Biphenyl Compounds - metabolism</subject><subject>Cytokines - biosynthesis</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Enzyme Inhibitors - therapeutic use</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Humans</subject><subject>Inflammation Mediators - metabolism</subject><subject>Interleukin-1alpha - biosynthesis</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Melanocytes - drug effects</subject><subject>Melanocytes - metabolism</subject><subject>Melanocytes - radiation effects</subject><subject>Monophenol Monooxygenase - antagonists & inhibitors</subject><subject>Phytotherapy</subject><subject>Picrates - metabolism</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Protein-Tyrosine Kinases - antagonists & inhibitors</subject><subject>Rheum</subject><subject>Rhizome</subject><subject>Skin - drug effects</subject><subject>Skin - metabolism</subject><subject>Skin - radiation effects</subject><subject>Skin Diseases - etiology</subject><subject>Skin Diseases - metabolism</subject><subject>Skin Diseases - prevention & control</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><subject>Ultraviolet Rays</subject><issn>1472-6882</issn><issn>1472-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kt1O2zAUx62JaQXGNXeTHwDT-CNOsotJA60UqRsTH9eWnTiLobGr2K3Wt6Iv0meaS0pFpSHZOvb5-_x0dP4G4BQn5xjnfIhZRhDPc4IwRaz4AA53mYM35wE48v4xSXCWY_YJDAhlLOV5dgiefzcuuFnngi6DWWgobRV3MO6vqWKEuq6j4qGr4W0zV7JTX6GxjVEmuG4JZaxyFsYVlp3zxkrfM7ZXDZ-2uQ3eBKP9i3z_a4TWqzN4PUF4vXpJrVfo590Yxl6qeU81FjbzVlrY6qm0rlwG7T-Dj7Wcen2yjcfgYfTj_nKMJjdX15ffJ0ixlATENNGVLFVBWaLTRKmc46wgrCYsVUWNM66zhHDFWc1YlhFVYCq5IiktWZxRTo_Bt547m6tWV6W2oZNTMetMK7ulcNKIfcWaRvxxC0HTIucsjYCLHqCMewewr5SuFRvHxMYxgalgRYQMe0gZp-k7Xe_qcSI2P-A_FV_e9r17_2o5_QemxbLe</recordid><startdate>20130227</startdate><enddate>20130227</enddate><creator>Silveira, Jéssica P S</creator><creator>Seito, Leonardo N</creator><creator>Eberlin, Samara</creator><creator>Dieamant, Gustavo C</creator><creator>Nogueira, Cecília</creator><creator>Pereda, Maria C V</creator><creator>Di Stasi, Luiz C</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20130227</creationdate><title>Photoprotective and antioxidant effects of Rhubarb: inhibitory action on tyrosinase and tyrosine kinase activities and TNF-α, IL-1α and α-MSH production in human melanocytes</title><author>Silveira, Jéssica P S ; Seito, Leonardo N ; Eberlin, Samara ; Dieamant, Gustavo C ; Nogueira, Cecília ; Pereda, Maria C V ; Di Stasi, Luiz C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b452t-4e2edacb9340e50bb8617924f245b9f176e7026b64f44772b913a6b253c481483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>alpha-MSH - biosynthesis</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Biphenyl Compounds - metabolism</topic><topic>Cytokines - biosynthesis</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Enzyme Inhibitors - therapeutic use</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Humans</topic><topic>Inflammation Mediators - metabolism</topic><topic>Interleukin-1alpha - biosynthesis</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Melanocytes - drug effects</topic><topic>Melanocytes - metabolism</topic><topic>Melanocytes - radiation effects</topic><topic>Monophenol Monooxygenase - antagonists & inhibitors</topic><topic>Phytotherapy</topic><topic>Picrates - metabolism</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Protein-Tyrosine Kinases - antagonists & inhibitors</topic><topic>Rheum</topic><topic>Rhizome</topic><topic>Skin - drug effects</topic><topic>Skin - metabolism</topic><topic>Skin - radiation effects</topic><topic>Skin Diseases - etiology</topic><topic>Skin Diseases - metabolism</topic><topic>Skin Diseases - prevention & control</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><topic>Ultraviolet Rays</topic><toplevel>online_resources</toplevel><creatorcontrib>Silveira, Jéssica P S</creatorcontrib><creatorcontrib>Seito, Leonardo N</creatorcontrib><creatorcontrib>Eberlin, Samara</creatorcontrib><creatorcontrib>Dieamant, Gustavo C</creatorcontrib><creatorcontrib>Nogueira, Cecília</creatorcontrib><creatorcontrib>Pereda, Maria C V</creatorcontrib><creatorcontrib>Di Stasi, Luiz C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silveira, Jéssica P S</au><au>Seito, Leonardo N</au><au>Eberlin, Samara</au><au>Dieamant, Gustavo C</au><au>Nogueira, Cecília</au><au>Pereda, Maria C V</au><au>Di Stasi, Luiz C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photoprotective and antioxidant effects of Rhubarb: inhibitory action on tyrosinase and tyrosine kinase activities and TNF-α, IL-1α and α-MSH production in human melanocytes</atitle><jtitle>BMC complementary and alternative medicine</jtitle><addtitle>BMC Complement Altern Med</addtitle><date>2013-02-27</date><risdate>2013</risdate><volume>13</volume><issue>1</issue><spage>49</spage><epage>49</epage><pages>49-49</pages><artnum>49</artnum><issn>1472-6882</issn><eissn>1472-6882</eissn><abstract>Exposure to ultraviolet (UV) radiation causes various forms of acute and chronic skin damage, including immunosuppression, inflammation, premature aging and photodamage. Furthermore, it induces the generation of reactive oxygen species, produces proinflammatory cytokines and melanocyte-stimulating hormone (MSH) and increases tyrosinase activity. The aim of this study was to evaluate the potential photoprotective effects of Rheum rhaponticum L. rhizome extract on human UV-stimulated melanocytes.
The effects of Rheum rhaponticum rhizome extract on tyrosine kinase activity, and on interleukin-1α (IL-1α), tumour necrosis factor α (TNF-α), and α-MSH production in human epidermal melanocytes were evaluated under UV-stimulated and non-stimulated conditions. Antioxidant activity was evaluated by lipid peroxidation and 1,1-dyphenyl-2-picryl-hydrazyl (DPPH) assays, while anti-tyrosinase activity was evaluated by the mushroom tyrosinase method.
Rheum rhaponticum L. rhizome extract showed in vitro antioxidant properties against lipid peroxidation, free radical scavenging and anti-tyrosinase activities, and inhibited the production of IL-1α, TNF-α, α-MSH, and tyrosine kinase activity in melanocytes subjected to UV radiation.
These results support the inclusion of Rheum rhaponticum L. rhizome extract into cosmetic, sunscreen and skin care products for the prevention or reduction of photodamage.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>23445687</pmid><doi>10.1186/1472-6882-13-49</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; PubMed Central |
| subjects | alpha-MSH - biosynthesis Antioxidants - pharmacology Antioxidants - therapeutic use Biphenyl Compounds - metabolism Cytokines - biosynthesis Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Free Radical Scavengers - pharmacology Humans Inflammation Mediators - metabolism Interleukin-1alpha - biosynthesis Lipid Peroxidation - drug effects Melanocytes - drug effects Melanocytes - metabolism Melanocytes - radiation effects Monophenol Monooxygenase - antagonists & inhibitors Phytotherapy Picrates - metabolism Plant Extracts - pharmacology Plant Extracts - therapeutic use Protein-Tyrosine Kinases - antagonists & inhibitors Rheum Rhizome Skin - drug effects Skin - metabolism Skin - radiation effects Skin Diseases - etiology Skin Diseases - metabolism Skin Diseases - prevention & control Tumor Necrosis Factor-alpha - biosynthesis Ultraviolet Rays |
| title | Photoprotective and antioxidant effects of Rhubarb: inhibitory action on tyrosinase and tyrosine kinase activities and TNF-α, IL-1α and α-MSH production in human melanocytes |
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