Giant prolactinoma: case report and review of literature
“Invasive giant prolactinoma” is a large prolactinoma (>4 cm in dimension) presenting with serum prolactin levels of >1000 ng/dL and mass related clinical symptoms. Here we report a patient with a giant prolactinoma presented with central hypogonadism, suppressed adrenal and thyroid function,...
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| Veröffentlicht in: | Journal of diabetes and metabolic disorders 2013-01, Vol.12 (1), p.3-3, Article 3 |
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| container_title | Journal of diabetes and metabolic disorders |
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| creator | Rahmanian, Masoud Meybodi, Hamidreza Aghaei Larijani, Bagher Mohajeri-Tehrani, Mohammad-reza |
| description | “Invasive giant prolactinoma” is a large prolactinoma (>4 cm in dimension) presenting with serum prolactin levels of >1000 ng/dL and mass related clinical symptoms. Here we report a patient with a giant prolactinoma presented with central hypogonadism, suppressed adrenal and thyroid function, supra sellar extension, visual field impairment and high prolactin level.
The patient was treated with cabergoline, levothyroxin and prednisolone. After 18 months, tumor size markedly reduced, associated with adrenal function and visual field improvement, but central hypogonadism and secondary hypothyroidism persisted.
Previous studies showed normalization of thyrotropin secretion after treatment but it remained low in our patient even after 18 months follow up. |
| doi_str_mv | 10.1186/2251-6581-12-3 |
| format | Article |
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The patient was treated with cabergoline, levothyroxin and prednisolone. After 18 months, tumor size markedly reduced, associated with adrenal function and visual field improvement, but central hypogonadism and secondary hypothyroidism persisted.
Previous studies showed normalization of thyrotropin secretion after treatment but it remained low in our patient even after 18 months follow up.</description><identifier>ISSN: 2251-6581</identifier><identifier>EISSN: 2251-6581</identifier><identifier>DOI: 10.1186/2251-6581-12-3</identifier><identifier>PMID: 23497585</identifier><language>eng</language><publisher>London: BioMed Central</publisher><subject>Care and treatment ; Case Report ; Corticosteroids ; Diabetes ; Endocrinology ; Hypothyroidism ; Medicine & Public Health ; Metabolic Diseases ; Prednisolone ; Prolactin ; Thyroid hormones ; Thyrotropin</subject><ispartof>Journal of diabetes and metabolic disorders, 2013-01, Vol.12 (1), p.3-3, Article 3</ispartof><rights>Rahmanian et al.; licensee BioMed Central Ltd. 2013</rights><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>Copyright ©2013 Rahmanian et al.; licensee BioMed Central Ltd. 2013 Rahmanian et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b553t-e3de00e3a51fb8192f85638a2843efe434f828734168a19b56c38a3f6d12fe6a3</citedby><cites>FETCH-LOGICAL-b553t-e3de00e3a51fb8192f85638a2843efe434f828734168a19b56c38a3f6d12fe6a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598222/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598222/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23497585$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rahmanian, Masoud</creatorcontrib><creatorcontrib>Meybodi, Hamidreza Aghaei</creatorcontrib><creatorcontrib>Larijani, Bagher</creatorcontrib><creatorcontrib>Mohajeri-Tehrani, Mohammad-reza</creatorcontrib><title>Giant prolactinoma: case report and review of literature</title><title>Journal of diabetes and metabolic disorders</title><addtitle>J Diabetes Metab Disord</addtitle><addtitle>J Diabetes Metab Disord</addtitle><description>“Invasive giant prolactinoma” is a large prolactinoma (>4 cm in dimension) presenting with serum prolactin levels of >1000 ng/dL and mass related clinical symptoms. Here we report a patient with a giant prolactinoma presented with central hypogonadism, suppressed adrenal and thyroid function, supra sellar extension, visual field impairment and high prolactin level.
The patient was treated with cabergoline, levothyroxin and prednisolone. After 18 months, tumor size markedly reduced, associated with adrenal function and visual field improvement, but central hypogonadism and secondary hypothyroidism persisted.
Previous studies showed normalization of thyrotropin secretion after treatment but it remained low in our patient even after 18 months follow up.</description><subject>Care and treatment</subject><subject>Case Report</subject><subject>Corticosteroids</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Hypothyroidism</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Prednisolone</subject><subject>Prolactin</subject><subject>Thyroid hormones</subject><subject>Thyrotropin</subject><issn>2251-6581</issn><issn>2251-6581</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp1kk1LAzEQhoMoKurVoywI3lY3ySabehBK8QsEL3oO2eykjewmJUkV_70p1dKiJocM877zMMwEoVNcXWIs-BUhDJecCVxiUtIddLhO7G7EB-gkxrcqn6YRAvN9dEBoPWqYYIdI3FvlUjEPvlc6WecHdV1oFaEIMPchFcp1OXy38FF4U_Q2QVBpEeAY7RnVRzj5fo_Q693ty-ShfHq-f5yMn8qWMZpKoB1UFVDFsGkFHhEjGKdCEVFTMFDT2ggiGlpjLhQetYzrrFLDO0wMcEWP0M2KO1-0A3QaXAqql_NgBxU-pVdWbivOzuTUv0vKRoIQkgHjFaC1_h_AtqL9IJfDk8vhSUwkzYzzFWOqepDWGZ-derBRyzGjtaCM8ya7Lv9w5dvBYLV3YGzObxVcbBTMQPVpFn2_SNa7-CdZBx9jALNuH1dy-RV-N3y2ObW1_Wfx2XC1MsQsuSkE-eYXweVN_of8Avl1u_0</recordid><startdate>20130108</startdate><enddate>20130108</enddate><creator>Rahmanian, Masoud</creator><creator>Meybodi, Hamidreza Aghaei</creator><creator>Larijani, Bagher</creator><creator>Mohajeri-Tehrani, Mohammad-reza</creator><general>BioMed Central</general><general>BioMed Central Ltd</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20130108</creationdate><title>Giant prolactinoma: case report and review of literature</title><author>Rahmanian, Masoud ; Meybodi, Hamidreza Aghaei ; Larijani, Bagher ; Mohajeri-Tehrani, Mohammad-reza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b553t-e3de00e3a51fb8192f85638a2843efe434f828734168a19b56c38a3f6d12fe6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Care and treatment</topic><topic>Case Report</topic><topic>Corticosteroids</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Hypothyroidism</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Prednisolone</topic><topic>Prolactin</topic><topic>Thyroid hormones</topic><topic>Thyrotropin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rahmanian, Masoud</creatorcontrib><creatorcontrib>Meybodi, Hamidreza Aghaei</creatorcontrib><creatorcontrib>Larijani, Bagher</creatorcontrib><creatorcontrib>Mohajeri-Tehrani, Mohammad-reza</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of diabetes and metabolic disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rahmanian, Masoud</au><au>Meybodi, Hamidreza Aghaei</au><au>Larijani, Bagher</au><au>Mohajeri-Tehrani, Mohammad-reza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Giant prolactinoma: case report and review of literature</atitle><jtitle>Journal of diabetes and metabolic disorders</jtitle><stitle>J Diabetes Metab Disord</stitle><addtitle>J Diabetes Metab Disord</addtitle><date>2013-01-08</date><risdate>2013</risdate><volume>12</volume><issue>1</issue><spage>3</spage><epage>3</epage><pages>3-3</pages><artnum>3</artnum><issn>2251-6581</issn><eissn>2251-6581</eissn><abstract>“Invasive giant prolactinoma” is a large prolactinoma (>4 cm in dimension) presenting with serum prolactin levels of >1000 ng/dL and mass related clinical symptoms. Here we report a patient with a giant prolactinoma presented with central hypogonadism, suppressed adrenal and thyroid function, supra sellar extension, visual field impairment and high prolactin level.
The patient was treated with cabergoline, levothyroxin and prednisolone. After 18 months, tumor size markedly reduced, associated with adrenal function and visual field improvement, but central hypogonadism and secondary hypothyroidism persisted.
Previous studies showed normalization of thyrotropin secretion after treatment but it remained low in our patient even after 18 months follow up.</abstract><cop>London</cop><pub>BioMed Central</pub><pmid>23497585</pmid><doi>10.1186/2251-6581-12-3</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of diabetes and metabolic disorders, 2013-01, Vol.12 (1), p.3-3, Article 3 |
| issn | 2251-6581 2251-6581 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Care and treatment Case Report Corticosteroids Diabetes Endocrinology Hypothyroidism Medicine & Public Health Metabolic Diseases Prednisolone Prolactin Thyroid hormones Thyrotropin |
| title | Giant prolactinoma: case report and review of literature |
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