Genetic variants of the class A scavenger receptor gene are associated with coronary artery disease in Chinese

Genetic variants of the class A scavenger receptor gene are associated with coronary artery disease in Chinese

The class A scavenger receptor, encoded by the macrophage scavenger receptor 1 （MSR1） gene, is a pattern recognition receptor （PPR） primarily expressed in macrophages. It has been reported that genetic polymorphisms of MSR1 are significantly associated with the number of diseased vessels and coronar...

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Veröffentlicht in:Journal of biomedical research 2012-11, Vol.26 (6), p.418-424
Hauptverfasser: Zhang, Min, Zhang, Yan, Zhu, Shuaishuai, Li, Xiaoyu, Yang, Qing, Bai, Hui, Chen, Qi
Format: Artikel
Sprache:eng
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Chinese population
class A scavenger receptor gene
coronary artery disease
Research Paper
single nucleotide polymorphisms (SNPs)
中国人群
冠状动脉疾病
单核苷酸多态性
受体基因
巨噬细胞
清道夫受体
遗传变异
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container_end_page 424
container_issue 6
container_start_page 418
container_title Journal of biomedical research
container_volume 26
creator Zhang, Min
Zhang, Yan
Zhu, Shuaishuai
Li, Xiaoyu
Yang, Qing
Bai, Hui
Chen, Qi
description The class A scavenger receptor, encoded by the macrophage scavenger receptor 1 （MSR1） gene, is a pattern recognition receptor （PPR） primarily expressed in macrophages. It has been reported that genetic polymorphisms of MSR1 are significantly associated with the number of diseased vessels and coronary artery narrowing greater than 20% in Caucasians. However, whether it links genetically to coronary artery disease （CAD） in Chinese is not defined. Here, we performed an independent case-control study in a Chinese population consisting of 402 CAD cases and 400 controls by genotyping ten single nucleotide polymorphisms （SNPs） of MSR1. We found that rs416748 and rs13306541 were significantly associated with an increased risk of CAD with per allele odds ratio （OR） of 1.56 [95% confidence interval （CI） = 1.28-1.90; P 〈 0.001] and 1.70 （95% CI = 1.27-2.27; P 〈 0.001）, re- spectively. Our results indicate that genetic variants of MSR1 may serve as predictive markers for the risk of CAD / in combination with traditional risk factors of CAD in Chinese population.
doi_str_mv 10.7555/JBR.26.20110116
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It has been reported that genetic polymorphisms of MSR1 are significantly associated with the number of diseased vessels and coronary artery narrowing greater than 20% in Caucasians. However, whether it links genetically to coronary artery disease （CAD） in Chinese is not defined. Here, we performed an independent case-control study in a Chinese population consisting of 402 CAD cases and 400 controls by genotyping ten single nucleotide polymorphisms （SNPs） of MSR1. We found that rs416748 and rs13306541 were significantly associated with an increased risk of CAD with per allele odds ratio （OR） of 1.56 [95% confidence interval （CI） = 1.28-1.90; P 〈 0.001] and 1.70 （95% CI = 1.27-2.27; P 〈 0.001）, re- spectively. 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subjects Chinese population
class A scavenger receptor gene
coronary artery disease
Research Paper
single nucleotide polymorphisms (SNPs)
中国人群
冠状动脉疾病
单核苷酸多态性
受体基因
巨噬细胞
清道夫受体
遗传变异
title Genetic variants of the class A scavenger receptor gene are associated with coronary artery disease in Chinese
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