Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells

Human epidermal stem cells express high levels of β1 integrins, delta-like 1 (DLL1) and the EGFR antagonist LRIG1. However, there is cell-to-cell variation in the relative abundance of DLL1 and LRIG1 mRNA transcripts. Single-cell global gene expression profiling showed that undifferentiated cells fe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Development (Cambridge) 2013-04, Vol.140 (7), p.1433-1444
Hauptverfasser:	Tan, David W M, Jensen, Kim B, Trotter, Matthew W B, Connelly, John T, Broad, Simon, Watt, Fiona M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - analysis Biomarkers - metabolism Cell Differentiation - genetics Cell Differentiation - physiology Cells, Cultured Development and Stem Cells Epidermis - cytology Epidermis - metabolism Epidermis - physiology Epithelial Cells - metabolism Epithelial Cells - physiology Gene Expression Profiling - methods Genetic Heterogeneity Humans Keratinocytes - metabolism Keratinocytes - physiology Microarray Analysis Models, Biological Polymerase Chain Reaction - methods Single-Cell Analysis - methods Stem Cells - metabolism Stem Cells - physiology Validation Studies as Topic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!