The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1

Angiogenesis plays an important role in cancer and in many other human diseases. Vascular endothelial growth factor-A (VEGF-A), the best known angiogenic factor, was originally discovered as a potent vascular permeability factor (VPF), suggesting that other vascular permeabilizing agents, such as hi...

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Veröffentlicht in:	Blood 2013-03, Vol.121 (11), p.2154-2164
Hauptverfasser:	Qin, Liuliang, Zhao, Dezheng, Xu, Jianfeng, Ren, Xianghui, Terwilliger, Ernest F., Parangi, Sareh, Lawler, Jack, Dvorak, Harold F., Zeng, Huiyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Capillary Permeability - drug effects Cells, Cultured Female Histamine - pharmacology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Human Umbilical Vein Endothelial Cells - physiology Humans Mice Mice, Inbred C57BL Mice, Knockout Mice, Nude Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - genetics Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism Nuclear Receptor Subfamily 4, Group A, Member 1 - physiology Protein Processing, Post-Translational - drug effects Protein Processing, Post-Translational - genetics Serotonin - pharmacology Thrombospondin 1 - metabolism Thrombospondin 1 - physiology Up-Regulation - drug effects Up-Regulation - genetics Vascular Biology
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