Inhibition of Fatty Acid Synthase Attenuates CD44-Associated Signaling and Reduces Metastasis in Colorectal Cancer

Fatty acid synthase (FASN) and ATP-citrate lyase, key enzymes of de novo lipogenesis, are significantly upregulated and activated in many cancers and portend poor prognosis. Even though the role of lipogenesis in providing proliferative and survival advantages to cancer cells has been described, the...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2012-03, Vol.72 (6), p.1504-1517
Hauptverfasser:	ZAYTSEVA, Yekaterina Y, RYCHAHOU, Piotr G, EVERS, B. Mark, GULHATI, Pat, ELLIOTT, Victoria A, MUSTAIN, William C, O'CONNOR, Kathleen, MORRIS, Andrew J, SUNKARA, Manjula, WEISS, Heidi L, LEE, Eun Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin AKT protein Animals Antineoplastic agents Biological and medical sciences CD44 antigen Cell Line, Tumor Cell migration Cell survival Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Cytoskeleton Down-Regulation - genetics Enzymes Fatty Acid Synthases - antagonists & inhibitors Fatty Acid Synthases - genetics Fatty Acid Synthases - metabolism Fatty-acid synthase Focal adhesion kinase Focal Adhesion Kinase 1 - analysis Gastroenterology. Liver. Pancreas. Abdomen Gene Knockdown Techniques Humans Hyaluronan Receptors - metabolism Lipogenesis Lipogenesis - genetics Liver Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - secondary Male Medical sciences Membrane proteins Metastases Mice Mice, Nude Oncogene Protein v-akt - analysis paxillin Paxillin - analysis Pharmacology. Drug treatments Prognosis Proto-Oncogene Proteins c-met - analysis Signal Transduction Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors Xenograft Model Antitumor Assays Xenografts
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